2006年，山東大學(xué)動物科學(xué)專業(yè)本科畢業(yè)。2011年，山東大學(xué)動物學(xué)專業(yè)博士畢業(yè)，同年入職河南師范大學(xué)。主持完成了國家自然科學(xué)基金青年基金和面上項目，河南省自然科學(xué)基金，河南省基礎(chǔ)與前沿項目，河南省科技攻關(guān)項目等。以第一作者或者通訊作者發(fā)表SCI論文17篇。

   主要從事水產(chǎn)動物先天免疫系統(tǒng)的研究。主要研究內(nèi)容包括模式識別受體如C型凝集素的功能，Toll樣受體對細(xì)菌和病毒的識別和激活免疫的方式，血細(xì)胞吞噬細(xì)菌或病毒的機(jī)制，以及抗菌效應(yīng)分子的活性等。

中國水產(chǎn)學(xué)會會員、中國動物學(xué)會會員、中國生化與分子生物學(xué)學(xué)會會員。

主持：

1. 螯蝦甘露糖受體抗白斑綜合征病毒研究，編號31873047，國家自然科學(xué)基金面上項目，2019.01-2020.12。

2. 螯蝦含免疫球蛋白結(jié)構(gòu)域C-型凝集素的免疫功能研究, 編號31301883，國家自然科學(xué)基金青年基金項目，2014.01-2016.12。

3. 河南省自然科學(xué)基金優(yōu)秀青年科學(xué)基金，編號242300421115，2024.01-2025.12。

4. 河南省留學(xué)人員科研擇優(yōu)資助項目。

5. 中華絨螯蟹C-型凝集素參與白斑綜合征病毒感染的機(jī)制研究，編號162300410166，河南省自然科學(xué)基金項目。2017.01-2018.12。

6. 螯蝦致病菌鞭毛蛋白受體的抗菌作用和漁藥應(yīng)用，編號212102110380，河南省科技攻關(guān)項目。2021.01-2022.12。

7. 螯蝦甘露糖受體抗白斑綜合征病毒研究，編號20180554，河南師范大學(xué)優(yōu)秀青年科學(xué)基金2018.01-2020.12。

8. 螯蝦中含免疫球蛋白結(jié)構(gòu)域的C型凝集素抗病作用研究，編號132300410140，河南省基礎(chǔ)與前沿技術(shù)研究計劃項目，2013.01-2015.12。

9. 中華絨螯蟹模式識別受體參與病原防御的分子機(jī)制研究，編號12A180018，河南省教育廳科學(xué)技術(shù)研究重點項目，2012.01-2014.12。

參與：

1. 對蝦抗病毒相關(guān)基因的功能與抗病毒機(jī)理分析，編號31130056，國家自然科學(xué)基金重點項目，2012.01-2016.12，參與。

2.生物乙醇生產(chǎn)菌株改良研究，編號082102220012，河南省科技廳，2008.01-2010.12，參與。

代表性論文：

1.Xia XH#, Liang N#, Ma XY, Qin L, Chang ZJ, Zhang XW*. Effect of dietary supplementation with Leuconostoc mesenteroides DH on the antimicrobial capacity and overall health of juvenile loach (Misgurnus anguillicaudatus).Aquaculture. 579: 740208. (2024).

2.Xia XH#, Guo WW#, Ma XY, Liang N, Duan XY, Zhang PH, Zhang Y, Chang ZJ, Zhang XW*. Reproductive toxicity and cross-generational effect of polyethylene microplastics in Paramisgurnus dabryanus. Chemosphere. 313: 137440.(2023).

3.Jin ZY, Shen ML, Wang LE, Wang C, Gao MM, Yu GY, Chang ZJ*, Zhang XW*.Antibacterial and immunoregulatory activity of an antimicrobial peptide hepcidin in loach (Misgurnus anguillicaudatus).  International Journal of Biological Macromolecules 242: 124833.(2023).

4.Zhang XW, Shen ML, Wang C, Gao MM, Wang LE, Jin ZY, Xia XH*.Impact of aluminum exposure on oxidative stress, intestinal changes and immuneresponses in red swamp crayfish (Procambarus clarkii). Science of theTotal Environment. 855: 158902 (2023).

5.Zhang XW, Jin ZY, Shen ML, Chang ZJ, Yu GY, Wang L, Xia XH*.Accumulation of polyethylene microplastics induces oxidative stress, microbiome dysbiosis and immunoregulation in crayfish. Fish & Shellfish Immunology.125:276-284(2022).

6.Xia XH, Liu GP, Wu XL, Cui SS, Yang CH, Du QY, Zhang XW*. Effects of Macleaya cordata extract on TLR20 and the proinflammatory cytokines in acute spleen injury of loach (Misgurnus anguillicaudatus) against Aeromonas hydrophila infection. Aquaculture.544, 737105. (2021)

7.Zhang XW, Han KK, Yang CH, Xia XH, Ren Q, Zhang HW. Astomach-specific lectin plays a crucial role in the innate immunity of redswamp crayfish, Procambarus clarkia. Fish & Shellfish Immunology.103:285-292(2020).

8.Zhang XW, Yang CH, Xia XH, Pan XT, Jin ZY, Yu H, Zhang HW. Atriple WAP domain containing protein acts in antibacterial immunity of weatherloach, Misgurnus anguillicaudatus. Fish & Shellfish Immunology.103,277-284 (2020).

9.Zhang XW, Yang CH, Zhang HQ, Pan XT, Jin ZY, Zhang HW, XiaXH. A C-type lectin with antibacterial activity in weather loach, Misgurnus anguillicaudatus. Journal of Fish Diseases. (2020).

10.Zhang XW*,Wang Y, Wang XW, Wang L, Mu Y, Wang JX*.A C-type lectin with an immunoglobulin-like domain promotes phagocytosis of hemocytes in crayfish Procambarus clarkii.Scientific Reports. 6, 29924. (2016).

11.Zhang XW,Wang XW,Huang Y,Hui KM, Shi YR,Wang W*, Ren Q*. Cloning and characterization of two different ficolins from the giant freshwater prawn Macrobrachium rosenbergii.Developmentaland Comparative Immunology. 44(2), 359-69 (2014).

12.Zhang XW,Xu WT, Wang XW, Mu Y, Zhao XF, Yu XQ, Wang JX. A novel C-type lectin with twoCRD domains from Chinese shrimp Fenneropenaeus chinensis functions as a pattern recognition protein. Molecular Immunology.46(8-9), 1626-37 (2009).

13.Zhang XW,Wang XW, Sun C, Zhao XF, Wang JX. C-type lectin (Pc-Lec1) from freshwater crayfish Procambarus clarkii and itsfunction in hemocyte encapsulation. Archivesof Insect Biochemistry and Physiology 76 (3), 168-84 (2011).

14.Pan XT, Li TT, Yang CH, Ren Q, Zhang XW*.A toll receptor is involved in antibacterial defense in the oriental riverprawn, Macrobrachium nipponense. Fish & Shellfish Immunology.92, 583-589 (2019).

15.Zhang XW,Man X, Huang X, Wang Y, Song QS, Hui KM*,Zhang HW*. Identification of a C-type lectin possessing both antibacterial and antiviral activities from redswamp crayfish. Fish & Shellfish Immunology.77, 22-30 (2018).

16.Li TT, Ding ZF, Pan XT, Ma FT, Han KK, Wu L, Zhao LL, Ren Q?, Zhang XW*. Characterization of an immune deficiency (IMD) homologfrom the oriental river prawn, Macrobrachium nipponense. Fish & Shellfish Immunology.83, 115-122 (2018).

17.Man X, Pan XT, Zhang HW, Wang Y, Li XC*,Zhang XW*. A mannose receptor is involved in the anti-Vibrio defense of redswamp crayfish. Fish & Shellfish Immunology.82, 258-266 (2018).