| 教育與研究經(jīng)歷: 1997,09- 2001,07河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院化學(xué)教育專(zhuān)業(yè)理學(xué)學(xué)士 2001,09 - 2004,07河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院有機(jī)化學(xué)專(zhuān)業(yè)理學(xué)碩士 2004,08 -2007,07 北京大學(xué)藥學(xué)院,天然產(chǎn)物與仿生藥物國(guó)家重點(diǎn)實(shí)驗(yàn)室,化學(xué)生物學(xué)專(zhuān)業(yè)博士 2009,12-2010,06美國(guó)內(nèi)華達(dá)大學(xué)醫(yī)學(xué)院,生理學(xué)系,NIH訪問(wèn)學(xué)者 2011, 12- 2012.12美國(guó)Scripps研究所,化學(xué)生物學(xué)專(zhuān)業(yè)博士后 2007,07-至今河南師范大學(xué)化學(xué)與化工學(xué)院副教授,教授 主講課程: 《化學(xué)生物學(xué)概論》,《核酸藥物化學(xué)》,《波譜分析與實(shí)驗(yàn)》 研究領(lǐng)域與興趣: 核酸化學(xué)生物學(xué),生物有機(jī)化學(xué),高通量化學(xué)生物學(xué)方法 近年來(lái)主持的主要科研項(xiàng)目: 國(guó)家自然科學(xué)基金項(xiàng)目(21778015): 蛋白質(zhì)ADP-核糖化穩(wěn)定結(jié)構(gòu)模擬物的設(shè)計(jì)合成及化學(xué)遺傳學(xué)研究(2018-2021) 國(guó)家自然科學(xué)基金項(xiàng)目(21172058): 基于靶導(dǎo)向合成(TGS)策略新型NAD+類(lèi)似物的設(shè)計(jì)合成及活性研究(2012-2015) 河南省科技創(chuàng)新杰出青年支持計(jì)劃(164100510020:基于人造基因密碼的核酸定點(diǎn)標(biāo)記技術(shù)及應(yīng)用(2016-2018) 河南省高校創(chuàng)新人才支持計(jì)劃(2012HASTIT10): 新型核苷酸類(lèi)細(xì)胞信號(hào)分子的設(shè)計(jì)合成及活性研究(2012-2014) 國(guó)家自然科學(xué)基金項(xiàng)目(20802017): 基于click化學(xué)的新型簡(jiǎn)單結(jié)構(gòu)cADPR 類(lèi)似物的設(shè)計(jì)合成及活性研究 (2009-2011) 代表性論文:
Feldman, Aaron W.;? Dien, Vivian T.;? Karadeema, Rebekah J.; Fischer, Emil C.; You, Yanbo; Chen, Jason S; Li, Lingjun.*; Romesberg, Floyd. E.* Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism. J. Am. Chem. Soc. 2019, 141 (27), 10644-10653. (IF = 14.357) Li, Lingjun; Degardin, Melissa; Lavergne, Thomas; Malyshev, Denis A.; Dhami, Kirandeep; Ordoukhanian, Phillip; Romesberg, Floyd E.* Natural-like Replication of an Unnatural Base Pair for the Expansion of the Genetic Alphabet and Biotechnology Applications. J. Am. Chem. Soc. 2014, 136 (3), 826-829. (IF = 14.357) Zhang, Yorke; Lamb, Brian M; Feldman, Aaron W; Zhou, Anne Xiaozhou; Lavergne, Thomas; Li, Lingjun; Romesberg, Floyd E*. A semisynthetic organism engineered for the stable expansion of the genetic alphabet. Proc. Natl. Acad. Sci. U S A 2017, 114 (6), 1317-1322. (IF = 9.674) Zhu, Anlian; Li, Lingjun;* Zhang, Chi; Shen Yutan; Tang, Mingjie, Bai, Lili; Du, Chunyan; Zhang, Suojiang; Wang, Jianji* An Integrated High-throughput Strategy Enables the Discovery of Multifunctional Ionic Liquids for Sustainable Chemical Processes. Green Chem. 2019, 21(2), 307-313. (IF = 9.405) Zhu, Anlian;* Xing, Xiaofang; Wang, Shilei; Yuan, Donghe; Zhu, Gongmin; Geng, Mingwei; Guo, Yuanyang; Zhang, Guisheng; Li, Lingjun* Multi-component Syntheses of Diverse 5-Fluoroalkyl-1,2,3-triazoles Facilitated by Air Oxidation and Copper Catalysis. Green Chem. 2019, 21 (12), 3407- 3412 (IF = 9.405) Li, Lingjun*; Ding, Shengqiang; Yang, Yanping; Zhu, Anlian; Fan, Xincui; Cui, Mengchao*; Chen, Changpo; Zhang, Guisheng*. Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles: Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling. Chemistry-A European Journal 2017, 23 (5), 1166-1172. (IF = 5.160) Li, Lingjun;* Huang, Shenlong; Shang, Tongpeng, Zhang, Bo; Guo, Yuanyang; Zhu, Gongming; Zhou, Demin;* Zhang, Guisheng;* Zhu, Anlian; Zhang Lihe. Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands. J. Org. Chem. 2018, 83(21), 13166?13177. (IF = 4.85) Lavergne, T.; Lamichhane, R.; Malyshev, D. A.; Li, Zhengtao Li; Li, Lingjun; Sperling, Edit ; Williamson, James R.; Millar, David P.; Romesberg. Floyd E. FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs. ACS Chem. Biol., 2016. 11(5), 1347?1353. (IF = 5.331)
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