朱功名
朱功名，博士，副教授（內(nèi)聘）， Email:zhugm1201@163.com，辦公地點：化北樓N614。
2017年畢業(yè)于蘭州大學(xué)，獲生物化學(xué)與分子生物學(xué)博士學(xué)位，目前主要從事手性藥物和多肽藥物的定向合成及關(guān)鍵技術(shù)的研究。在Angew. Chem. Int. Ed.，ACS Catal.，Org. Lett.等期刊發(fā)表論文15余篇；主持國家自然科學(xué)基金1項，省部級基金2兩項。
教育與研究經(jīng)歷:
2007年9月-2011年6月，河南師范大學(xué)，生命科學(xué)學(xué)院。
2011年9月-2017年6月，蘭州大學(xué)，生命科學(xué)學(xué)院，碩博連讀，博士。
2017年7月-2018年7月，中山大學(xué)，特聘副研究員，藥物化學(xué)研究。
2018年9月-至今，河南師范大學(xué)，化學(xué)化工學(xué)院。
主講課程：
《藥理學(xué)》，《生物化學(xué)》
研究領(lǐng)域及興趣：
主要研究領(lǐng)域：手性藥物和多肽藥物的定向合成及關(guān)鍵技術(shù)的開發(fā)。
潛在活性分子的不對稱合成新策略研究。
活性多肽后修飾及其化學(xué)生物學(xué)研究。
核酸多肽化學(xué)生物學(xué)研究。
今年來主持及參與的科研項目：
國家自然科學(xué)青年基金，2019-2021年，主持，資助金額：27.5萬元。
廣東省自然科學(xué)基金，2018-2021年，主持，資助金額：10萬元。
博士后基金面上項目一等資助，2018-2020年，主持，資助金額：8 萬元。
河南師范大學(xué)博士啟動經(jīng)費，2019-2021年，主持，資助金額：8萬。
參與完成國家自然科學(xué)青年基金2項，其中一項被評為優(yōu)秀；參與重點項目一項，面上項目一項。
代表論文：
[1] Gongming Zhu#, Guangjun Bao#, Yiping Li, Wangsheng Sun,* Jing Li, Liang Hong,* and Rui Wang*. Efficient Catalytic Kinetic Resolution of Spiro-epoxyoxindoles with Concomitant Asymmetric Friedel-Crafts Alkylation of Indoles. Angew. Chem. Int. Ed. 2017, 56, 5332 –5335.
[2] Wangsheng Sun#, Gongming Zhu#, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Organocatalytic Diastereo- and Enantioselective 1,3-Dipolar Cycloaddition of Azlactones and Methyleneindolinones. Angew. Chem. Int. Ed.2013, 52, 8633–8637.
[3] Gongming Zhu#, Yiping Li#, Guangjun Bao, Wangsheng Sun,* Liwu Huang, Liang Hong,* and Rui Wang*. Catalytic Kinetic Resolution of Spiro-Epoxyoxindoleswith 1 Naphthols: Switchable Asymmetric Tandem Dearomatization/Oxa-Michael Reaction and Friedel?Crafts Alkylation of 1 Naphthols at the C4 Position.ACS Catal.2018, 8, 1810?1816.
[4] Gongming Zhu, Guangjun Bao, Yiping Li, Junxian Yang, Wangsheng Sun, Jing Li, Liang Hong,* and Rui Wang*. Chiral Phosphoric Acid Catalyzed Asymmetric Oxidative Dearomatization of Naphthols with Quinones. Org. Lett., 2016, 18, 5288-5291.
[5] Gongming Zhu, Junxian Yang, Guangjun Bao, Ming Zhang, Jing Li, Yiping Li, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Catalyst-controlled switch of regioselectivity in the asymmetric allylic alkylation of oxazolones with MBHCs，Chem. Commun. 2016, 52, 7882-7885.
[6] Gongming Zhu, Wangsheng Sun, Chongyang Wu, Guofeng Li, Liang Hong,* and Rui Wang*. Base-Catalyzed Diastereoselective [3 + 3] Annulation of 3-Isothiocyanatooxindoles and Azomethine Imines. Org. Lett. 2013, 15, 4988.
[7] Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. “Organo - Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles. Chem. Eur. J. 2012, 18, 13959 – 13963.
[8] Wangsheng Sun, Gongming Zhu, Chongyang Wu, Liang Hong,* and Rui Wang*. An Organocatalytic Cascade Strategy for the Enantioselective Construction of Spirocyclopentane Bioxindoles Containing Three Contiguous Stereocenters and Two Spiro Quaternary Centers. Chem. Eur. J. 2012, 18, 6737 – 6741.
[9] Wangsheng Sun, Gongming Zhu, Liang Hong,* and Rui Wang*. The Marriage of Organocatalysis with Metal Catalysis: Access to Multisubstituted Chiral 2,5-Dihydropyrroles by Cascade Iminium/Enamine–Metal Cooperative Catalysis, Chem. Eur. J. 2011, 17, 13958 – 13962.
[10] Ming Zhang,1 Wangsheng Sun,1Gongming Zhu, Guangjun Bao, Bangzhi Zhang, Liang Hong,* Min Li,* and Rui Wang*.Enantioselective dearomative arylation of isoquinolines. ACS Catal. 2016, 6, 5290-5294.
[11] Zhenhua Zhang, Wangsheng Sun,* Gongming Zhu, Junxian Yang, Ming Zhang, Liang Hong,* and Rui Wang*. Chiral phosphoric acid catalyzed enantioselective 1,3-dipolar cycloaddition reaction of azlactones. Chem. Commun. 2016, 52, 1377-1380.
[12] Wangsheng Sun#,Liang Hong#, Gongming Zhu, Zilong Wang, Xiaojin Wei, Jingman Ni,* and Rui Wang*. organocatalytic michael-michael cascade for the enantioselective construction of spirocyclopentane bioxindoles: control of four contiguous stereocenters.Org. Lett.2014, 16, 544-547.
[13] Guofeng Li, Guangjun Bao, Gongming Zhu, Yiping Li, Liwu Huang, Wangsheng Sun,* Liang Hong* and Rui Wang*. Regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles. Org. Biomol. Chem., 2018,16, 3655-3661.
[14] Bangzhi Zhang, Yiping Li, Guangjun Bao, Gongming Zhu, Jing Li, Lijuan Wang, Bao Zhang, Wangsheng Sun,* Liang Hong,* and Rui Wang*. Regio- and stereoselective ring-opening reaction of spiro-epoxyoxindoles with ammonia under catalyst-free conditions. Green Chem. 2017, 19, 2107-2110.
[15] Zhixuan Zeng, Xudong Xun, Liwu Huang, Jiecheng Xu, Gongming Zhu, Guofeng Li, Wangsheng Sun,* Liang Hong* and Rui Wang*. Catalyst-free tandem halogenation/semipinacol rearrangement of allyl alcohols with sodium halide in water. Green Chem. 2018, 20, 2477-2480.
