郭勝海
郭勝海，博士、教授、碩士生導師
河南省優(yōu)秀碩士學位論文指導教師（2019、2020）
河南師范大學優(yōu)秀碩士學位論文指導教師（2016、2018、2019）
河南師范大學青年骨干教師（2015）
聯(lián)系方式：shguo@htu.cn
教育與研究經(jīng)歷
學習經(jīng)歷：
2000.9-2004.7 河南師范大學，化學專業(yè)，本科
2004.9-2009.7 中國科學院上海有機化學研究所，有機化學專業(yè)，博士
工作經(jīng)歷：
2009.7-2010.8 上海美迪西生物醫(yī)藥有限公司，化學研發(fā)部，課題組長
2010.9-2014.3 河南師范大學，化學化工學院，講師
2014.4-2022.3 河南師范大學，化學化工學院，副教授
2022.4-至今 河南師范大學，化學化工學院，教授
主講課程：
本科生：《有機合成化學》《有機化學實驗》
研究生：《有機合成設計技巧》
研究領域與興趣：
有機合成、藥物合成
近年來主持的科研項目:
1、國家自然科學基金項目(21202040): 5-雜芳環(huán)取代嘧啶核苷類似物的合成新方法及生物活性研究。
2、中國博士后科學基金面上資助(2014M552007): 新型5-雜芳環(huán)取代胞苷的合成及生物活性研究。
3、中國博士后科學基金特別資助(2015T80771): 基于銅催化串聯(lián)反應的氮稠雜環(huán)的構(gòu)筑及生物活性研究。
4、河南省科技攻關項目(192102310296): 含喹唑啉酮結(jié)構(gòu)單元的生物堿的高效合成及生物活性研究。
5、河南省高等學校重點科研項目計劃(20A150024): 三價銠催化的氧化螺環(huán)化反應研究。
代表性論文：
26. Shenghai Guo,* Ziyi Zhang, Zhaotong Wei, Yuanqing Zhu, and Xuesen Fan*. Rh(III)-Catalyzed Spiroannulation Reaction of N-Aryl Nitrones with 2-Diazo-1,3-indandiones: Synthesis of Spirocyclic Indole-N-oxides and Their 1,3-Dipolar Cycloaddition with Maleimides. J. Org. Chem., 2023, 88(6), 3845-3858.
25. Ziyi Zhang, Jin Wang, Shenghai Guo,* Jing Fan,* and Xuesen Fan*. t-BuOK-Catalyzed Regio- and Stereoselective Intramolecular Hydroamination Reaction Leading to Phthalazino- quinazolinone Derivatives. J. Org. Chem., 2023, 88(2), 1282-1291.
24. Shenghai Guo,* Ziyi Zhang, Yuanqing Zhu, Zhaotong Wei, Xinying Zhang and Xuesen Fan*. Rh(III)-Catalyzed Substrate-Dependent Oxidative (Spiro)annulation of Isoquinolones with Diazonaphthoquinones: Selective Access to New Spirocyclic and Oxepine-Fused Polycyclic Compounds. Org. Chem. Front., 2022, 9(23), 6598-6605.
23. Shenghai Guo,* Yangfan Liu, Yaping Wang, Xinying Zhang,* and Xuesen Fan*. Construction of Bridged Carbocycles and Heterocycles via Rh(III)-Catalyzed C-H Alkylation/Michael Addition of 2-Arylindoles with Quinone Monoacetals. J. Org. Chem., 2020, 85(14), 8910-8922.
22. Shenghai Guo,* Yangfan Liu, Xinying Zhang, and Xuesen Fan*. Iridium-Catalyzed Oxidative Annulation of 2-Arylindoles with Benzoquinone Leading to Indolo[1,2-f]phenanthridin-6-ols. Adv. Synth. Catal., 2020, 362(14), 3011-3020.
21. Shenghai Guo,* Lincong Sun, Xuzhuo Li, Xinying Zhang, and Xuesen Fan*. Selective Synthesis of Indazolo[2,3-a]quinolines via Rh(III)-Catalyzed Oxidant-Free [4+2] or [5+1] Annulation of 2-Aryl-2H-indazoles with α-Diazo Carbonyl Compounds. Adv. Synth. Catal., 2020, 362(4), 913-926.
20. Shenghai Guo*, Yangfan Liu, Lu Zhao, Xinying Zhang, and Xuesen Fan*. Rhodium-Catalyzed Selective Oxidative (Spiro)annulation of 2-Arylindoles by Using Benzoquinone as a C2 or C1 Synthon. Org. Lett., 2019, 21(16), 6437-6441.
19. Shenghai Guo,* Lincong Sun, Yangfan Liu, Nana Ma,* Xinying Zhang, and Xuesen Fan*. Rh(III)-Catalyzed Oxidative Spirocyclization of Isoquinolones with α-Diazo-1,3-indandiones. Org. Lett., 2019, 21(11), 4082-4086.
18. Shenghai Guo*,Lincong Sun, Fang Wang, Xinying Zhang, and Xuesen Fan.* Rh(III)-Catalyzed Oxidative Annulation of Isoquinolones with Diazoketoesters Featuring an in Situ Deacylation: Synthesis of Isoindoloisoquinolones and Their Transformation to Rosettacin Analogues. J. Org. Chem., 2018, 83(19), 12034-12043.
17. Shenghai Guo,* Fang Wang, Lincong Sun, Xinying Zhang, and Xuesen Fan.* Palladium-Catalyzed Oxidative Cyclocarbonylation of Isoquinolones with CO via C-H/N-H Bond Cleavage: Easy Access to Isoindolo[2,1-b]isoquinoline-5,7-dione Derivatives. Adv. Synth. Catal., 2018, 360(13), 2537-2545.
16. Shenghai Guo,* Fang Wang, Li Tao, Xinying Zhang, and Xuesen Fan.* Solvent-Dependent Copper-Catalyzed Indolyl C3-Oxygenation and N1-Cyclization Reactions: Selective Synthesis of 3H-Indol-3-ones and Indolo[1,2-c]quinazolines. J. Org. Chem., 2018, 83(7), 3889-3896.
15. Shenghai Guo,* Jianhui Zhai, Fang Wang, and Xuesen Fan.* One-pot three-component selective synthesis of isoindolo[2,1-a] quinazoline derivatives via a palladium-catalyzed cascade cyclocondensation/cyclocarbonylation sequence. Org. Biomol. Chem., 2017, 15(17), 3674–3680.
14. Shenghai Guo,* Jianhui Zhai, and Xuesen Fan.* An I-2-mediated cascade reaction of 2'-bromoacetophenones with benzohydrazides/ benzamides leading to quinazolino[3,2-b]cinnoline or tryptanthrin derivatives. Org. Biomol. Chem., 2017, 15(6), 1521–1529.
13. Shenghai Guo,* Li Tao, Fang Wang, and Xuesen Fan.* Pd-Catalyzed Cyclocarbonylation of 2-(2-Bromoaryl)indoles with CO as a C1 Source: Selective Access to 6H-Isoindolo[2,1-a]indol-6-ones and Indeno[1,2-b]indol-10(5H)-ones. Chem. Asian J., 2016, 11(21), 3090-3096.
12. Shenghai Guo,* Li Tao, Wenwen Zhang, Xinying Zhang, and Xuesen Fan*. Regioselective Synthesis of Indolo[1,2-c]quinazolines and 11H-Indolo[3,2-c]quinolines via Copper-Catalyzed Cascade Reactions of 2-(2-Bromoaryl)-1H-indoles with Aldehydes and Aqueous Ammonia. J. Org. Chem., 2015, 80(21), 10955?10964.
11. Shenghai Guo*, Jiliang Wang, Xinying Zhang, Sandrine Cojean, Philippe M. Loiseau, and Xuesen Fan*. Synthesis of 5-isoxazol-3-yl-pyrimidine nucleosides as potential antileishmanial agents. Bioorg. Med. Chem. Lett., 2015, 25(13), 2617–2620.
10. Shenghai Guo*,Yan Li, Li Tao, Wenwen Zhang, and Xuesen Fan*. Rapid assembly of quinazolinone scaffold via copper-catalyzed tandem reaction of 2-bromobenzamides with aldehydes and aqueous ammonia: application to the synthesis of the alkaloid tryptanthrin. RSC adv., 2014, 4(103), 59289-59296.
9. Shenghai Guo*, Jiliang Wang, Yan Li, and Xuesen Fan*. CuCl-catalyzed one-pot synthesis of 5,6-dihydropyrazolo[1,5-c]quinazolines. Tetrahedron, 2014, 70(14), 2383-2388.
8. Shenghai Guo*, Jiliang Wang, Xuesen Fan*, Xinying Zhang, and Dongqiang Guo. Synthesis of pyrazolo [1,5-c]quinazoline derivatives through copper-catalyzed tandem reaction of 5-(2-bromoaryl)-1H- pyrazoles with carbonyl compounds and aqueous ammonia. J. Org. Chem., 2013, 78(7), 3262-3270.
7. Shenghai Guo*, Jiliang Wang, Dongqiang Guo, Xinying Zhang, and Xuesen Fan*. Highly regioselective and practical synthesis of 1-acyl-5-hydroxypyrazolines and 1-acylpyrazoles from 1,2-allenic ketones and hydrazides. Tetrahedron, 2012, 68(38), 7768-7774.
6. Shenghai Guo*, Jiliang Wang, Dongqiang Guo, Xinying Zhang, and Xuesen Fan*. Synthesis of 3,5- disubstituted pyrazoles via cyclocondensation of 1,2-allenic ketones with hydrazines: application to the synthesis of 5-(5-methyl-pyrazol-3-yl)-2'-deoxycytidine. RSC Adv., 2012, 2(9), 3772-3777.
5. Shenghai Guo and Yuanhong Liu*. A facile Zr-mediated multicomponent approach to arylated allylic alcohols and its application to the synthesis of highly substituted indenes and spiroindenes. Org. Biomol. Chem., 2008, 6(12), 2064-2070.
4. Shenghai Guo, Hao Zhang, Feijie Song, and Yuanhong Liu*. Studies on the zirconium-mediated alkyne–aldehyde coupling reactions: a facile synthesis of stereodefined allylic alcohols and (Z)-2-en-4-yn-1-ols. Tetrahedron, 2007, 63(9), 2009-2018.
3. Shenghai Guo, Feijie Song, and Yuanhong Liu*. Gold-catalyzed direct amination of allylic alcohols. Synlett, 2007, (6), 964-968.
2. Yuanhong Liu,* Feijie Song, and Shenghai Guo. Cleavage of a carbon-carbon triple bond via gold-catalyzed cascade cyclization/oxidative cleavage reactions of (Z)-enynols with molecular oxygen. J. Am. Chem. Soc., 2006, 128(35), 11332-11333.
1. Yuanhong Liu,* Meina Liu, Shenghai Guo, Huamin Tu, Yebing Zhou, and Hongjun Gao. Gold-catalyzed highly efficient access to 3(2H)-furanones from 2-oxo-3-butynoates and related compounds. Org. Lett. 2006, 8(16), 3445-3448.
(1)郭勝海，王芳，范學森，一鍋三組分合成異吲哚[2,1-b]異喹啉-5,7-二酮類化合物的方法，2020.6.2，中國，ZL201810354218.5。
(2)郭勝海，翟劍輝，陶麗，范學森，一種常壓合成6H-異吲哚[2,1-a]吲哚-6-酮類化合物的方法，2019.1.1，中國，ZL201610735716.5。
(3)郭勝海，王芳，陶麗，范學森，一種茚[1,2-b]吲哚-10(5H)-酮類化合物的合成方法，2018.12.28，中國，ZL201610735774.8。
(4)郭勝海，王芳，翟劍輝，范學森，5H-喹唑啉[3,2-b]噌啉-7,13-二酮類化合物及其制備方法，2018.9.18，中國，ZL201710033227.X。
(5)郭勝海，翟劍輝，王芳，范學森，一種合成6,6a-二氫異吲哚[2,1-a]喹唑啉-5,11-二酮類化合物的方法，2018.11.27，中國，ZL201710206565.9。
(6)郭勝海，陶麗，范學森，張新迎，一種11H-吲哚并[3,2-c]喹啉類化合物的合成方法，2017.3.22，中國，ZL201510653298.0。
