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          李德明

          發(fā)布時(shí)間:2018-05-09






          姓   名:李德明

          職   稱:講師

          辦公電話:0373-3328084

          電子郵箱:041157@htu.edu.cn








          個人簡介:

             李德明,1994.9-1997.6在湖北工程學(xué)院生命科學(xué)學(xué)院生物科學(xué)專業(yè)學(xué)習(xí), 1997.9-2002.6在湖北省漢川市三星苑學(xué)校任生物學(xué)教師,2002.9-2005.6在湖北大學(xué)生命科學(xué)學(xué)院生態(tài)學(xué)專業(yè)學(xué)習(xí),獲碩士學(xué)位,2005.9-2008.12在四川大學(xué)生命科學(xué)學(xué)院動物學(xué)專業(yè)學(xué)習(xí),獲博士學(xué)位。主持河南省自然科學(xué)基金重點(diǎn)項(xiàng)目1項(xiàng),河南省高等學(xué)校重點(diǎn)科研項(xiàng)目1項(xiàng),作為主要參與人參與國家973前期研究專項(xiàng)2項(xiàng),國家自然科學(xué)基金項(xiàng)目1項(xiàng),河南省自然科學(xué)基金重點(diǎn)項(xiàng)目1項(xiàng)。發(fā)表SCI論文10篇,其中第一作者5篇。

          研究領(lǐng)域:
              研究領(lǐng)域?yàn)閯游锛?xì)胞生物學(xué),主要以大鼠和小鼠為材料,研究肝再生、肝纖維、肝硬化的發(fā)生、表觀調(diào)控及機(jī)理。
          主要學(xué)術(shù)及社會兼職:

          中國細(xì)胞生物學(xué)會會員,河南省實(shí)驗(yàn)動物學(xué)會會員。

          主持或參加科研項(xiàng)目情況:

          1.河南省自然科學(xué)基金重點(diǎn)項(xiàng)目:142300413227,蛋白/多肽誘導(dǎo)細(xì)胞分化機(jī)理及其應(yīng)用研究,2014/01- 2016/12, 20萬元, 已結(jié)題,主持。

          2.河南省高等學(xué)校重點(diǎn)科研項(xiàng)目:IL-1R1敲除對老年小鼠肝再生的作用機(jī)制研究,2019.1-2020.12,在研,主持。

          3.國家自然科學(xué)青年科學(xué)基金項(xiàng)目,31601038,一個大鼠肝再生相關(guān)的新lncRNA(rLALR1)調(diào)節(jié)肝細(xì)胞增殖的作用及機(jī)理研究,2017/01-2019/12,17萬,在研,參與。

          4.973前期研究專項(xiàng),2012CB722304,肝臟損傷修復(fù)與再生機(jī)制的蛋白質(zhì)組學(xué)基礎(chǔ)研究,2012/01–2014/12, 108萬元,已結(jié)題,參與。

          5.973前期研究專項(xiàng),2010CB534905, 大鼠肝再生蛋白質(zhì)組學(xué)研究, 2010/03-2012/12, 55萬元,已結(jié)題,參與。

          6.河南省自然科學(xué)基金項(xiàng)目:TSP-1調(diào)控大鼠肝細(xì)胞增殖的機(jī)理及臨床應(yīng)用研究。2014/01-2016/12, 35萬元,已結(jié)題,參與。

          學(xué)術(shù)成果:

          代表性論文:(按論文級別排序,高水平SCI靠前,按參考文獻(xiàn)格式寫)

          1. Deming Li, Jun Li, Gaiping Wang, Yanli Qin, Zhipeng Niu, Ziwei Li,Cunshuan Xu*, Delayed liver regeneration after partial hepatectomy in aged Nos2knockout mice. Cell J., 2017, 19(2): 218-230.

          2. Deming Li, Ziwei Li, Xueqiang Guo, Cunshuan Xu*. Restoration of CpGmethylation in the EGF promoter region during rat liver regeneration. Cell J.,2015, 17(3): 576-581.

          3. Deming Li, Jinyu Fan, Ziwei Li, Cunshuan Xu*. DNA methylation dynamicsin the rat EGF gene promoter after partial hepatectomy. Genet. Mol. Biol.,2014, 37(2), 439-443.

          4 Deming Li, Longqing Fan, Bo Zeng, Hailin Yin, Fangdong Zou,Hongxing Wang, Yang Meng, Emily King, Bisong Yue. The complete mitochondrialgenome of Macaca thibetana and a novel nuclear mitochondrial pseudogene.  Gene, 2009, 429:31-36.

          5. Deming Li, Longqin Fan, Jianghong Ran, Hailin Yin, Hongxing Wang,Shaobin Wu, Bisong Yue. Genetic diversity analysis of Macaca thibetanapopulations based on mitochondrial DNA control region sequences.  Mitochondrial DNA, 2008, 19(5):446-452.

          6. Cuifang Chang,ZhipengNiu,Ningning Gu,WeimingZhao,Gaiping Wang,Yifeng Jia,Deming Li,CunshuanXu*.Analysis of the ways and methods of signaling pathways in regulating cellcycle of NIH3T3 at transcriptional level. BMC Cell Biology, 2015, 16:25.

          7. Yi Ding, Cuifang Chang,Zhipeng Niu, Keqiang Dai, Xiaofang Geng, DemingLi, Jianlin Guo, Cunshuan Xu*.Overexpression of transcription factor Foxa2and Hnf1a induced rat bone mesenchymal stem cells into hepatocytes.Cytotechnology, 2016, 68:2037-2047.

          8. Jingyan Sun, XiaofangGeng, Jianlin Guo, Xiayan Zang, Pengfei Li, Deming Li, Cunshuan Xu*. Proteomic analysis of the skin fromChinese ?re-bellied newt and comparison to Chinese giant salamander.Comparative Biochemistry and Physiology, 2016, Part D 19: 71-77.

          9. Chunyan Zhang, CuifangChang, Deming Li, Fuchun Zhang,Cunshuan Xu*.The novel protein C3orf43 accelerates hepatocyte proliferation.Cellular & Molecular Biology Letters, 2017, 22:21.

          10.Chunyan Zhang, Cuifang Chang, Weiming Zhao, Hang Gao, QiwenWang, Deming Li, Fuchun Zhang, Shifu Zhang,Cunshuan Xu*.The novel protein C9orf116 promotes rat liver cell line BRL-3Aproliferation. 2017, PLOS ONE,12(7):e0180607.