2010年09月～2016年05月：在軍事醫(yī)學(xué)研究院生物工程研究所完成碩博課題；

2016年06月：獲首都師范大學(xué)遺傳學(xué)博士學(xué)位；

2016年12月～2018年11月：河南師范大學(xué)生物學(xué)流動(dòng)站在站博士后；

2018年12月～至今：河南師范大學(xué)生命科學(xué)學(xué)院講師、碩士生導(dǎo)師。

主持河南省重點(diǎn)研發(fā)與推廣專項(xiàng)（科技攻關(guān)）、河南省高等學(xué)校重點(diǎn)科研項(xiàng)目計(jì)劃、河南省博士后啟動(dòng)基金及河南師范大學(xué)博士科研啟動(dòng)基金等；參與國(guó)家自然科學(xué)基金和“973”等國(guó)家級(jí)項(xiàng)目。主講本科生《分子生物學(xué)》、《食品化學(xué)》等專業(yè)必修課程。指導(dǎo)本科生參加全國(guó)大學(xué)生生命科學(xué)競(jìng)賽暨河南省大學(xué)生生命科學(xué)競(jìng)賽，獲國(guó)家二/三等獎(jiǎng)、河南省一/二等獎(jiǎng)，并獲“優(yōu)秀指導(dǎo)教師”稱號(hào)。目前指導(dǎo)2名在讀碩士研究生。在FASEB J，BMC GENOMICS，iScience，F(xiàn)ront. Genet.，Biochem. Biophys. Res. Commun.，PeerJ，Mol. Biol.等SCI期刊和中文核心期刊發(fā)表科研論文30余篇。

表觀遺傳學(xué)，研究方向?yàn)槿S基因組的結(jié)構(gòu)與功能。

研究?jī)?nèi)容：（1）細(xì)胞周期表觀遺傳信息傳遞；（2）利用再生模型和肝病模型，通過(guò)多組學(xué)的整合分析解析肝再生及肝纖維化等表觀調(diào)控機(jī)制，尋找肝病的生物標(biāo)志物及靶點(diǎn)藥物。研究技術(shù)/方法包括但不限于Chromatin Conformation Capture（Hi-C）、(sc)ATAC-seq、ChIP-seq、(sc)CUT&Tag(Run)、HiCuT、Hi-TrAC、(sc)RNA-seq等。

  無(wú)

1. 河南省重點(diǎn)研發(fā)與推廣專項(xiàng)（科技攻關(guān)），222102310589，2022-01至2023-12，在研，主持

2. 河南省高等學(xué)校重點(diǎn)科研項(xiàng)目計(jì)劃，21A180009，2021-01至2022-12，已結(jié)題，主持

3. 河南師范大學(xué)博士科研啟動(dòng)基金，2020-01至2022-12，已結(jié)題，主持

4. 河南省博士后科研項(xiàng)目啟動(dòng)經(jīng)費(fèi)，001803040，2018-01至2018-12，已結(jié)題，主持

5. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，31370762，2014-01至2017-12，已結(jié)題，參加

6. 國(guó)家自然科學(xué)基金委員會(huì)，面上項(xiàng)目，81372218，2014-01至2017-12，已結(jié)題，參加

7. 國(guó)家重點(diǎn)基礎(chǔ)研究發(fā)展規(guī)劃，973項(xiàng)目，2013CB966802，2013-01至2017-08，已結(jié)題，參加

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2023

1. Bingyu Ye#, Wenlong Shen#, YanchangLi#, Dong Wang, Yan Zhang, Ping Li, Man Yin, Yahao Wang, Dejian Xie,Shu Shi, Tao Yao, Juncai Chen, Ping Xu*, Zhihu Zhao*. FAIRE-MS reveals mitotic retention of transcriptional regulators on a proteome-wide scale. The FASEB Journal, 2023, 37(2): e22724.

1. Bingyu Ye#, Wenlong Shen#, Chunyan Zhang#, Mengli Yu, Xinru Ding, Man Yin, Yahao Wang, Xinjie Guo, Ge Bai,Kailin Lin, Shu Shi, Ping Li, Yan Zhang, Guoying Yu*, Zhihu Zhao*. The role of ZNF143 overexpression in rat liver cell proliferation. BMC Genomics, 2022, 23: 483.

2. Wenlong Shen#, Yan Zhang#*, Minglei Shi#,Bingyu Ye, Man Yin, Ping Li, Yifei Jin, Zhang Zhang, Shu Shi, Michael Zhang, Yang Chen*, Zhihu Zhao*. Profiling and characterization of constitutive chromatin enriched RNAs. iScience, 2022,25: 105349.

3. Chunyan Zhang, Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Quo, Bingyu Ye*, GuoYing Yu*. Overview of microRNAs as diagnostic and prognostic biomarkers for high-incidence cancers in 2021. International Journal of Molecular Sciences, 2022, 23(19): 11389.

4. Chunyan Zhang, Yabin Zhao, Mengli Yu, Jianru Qin, Bingyu Ye*,Qiwen Wang*. Mitochondrial dysfunction and chronic liver disease. Current Issues in Molecular Biology, 2022,44: 3156-3165.

5. Yahao Wang#, Wenlong Shen#*, Man Yin, Wenhua Huang, Bingyu Ye, Ping Li, Shu Shi, Ge Bai, Xinjie Guo, Yifei Jin,Kailin Lin, Yan Zhang, Yongqiang Jiang*, Junfeng Wang*, Yanping Han*, Zhihu Zhao*. Changes in higher-Order chromosomal structure of Klebsiella pneumoniae under simulated microgravity. Frontiers in Microbiology, 2022, 13: 879321.

6.Chunyan Zhang,Yabin Zhao, Qiwen Wang, Jianru Qin, Bingyu Ye, Cunshuan Xu*,GuoYing Yu*. Overexpression of miR-125a-5p inhibits hepatocyte proliferation through the STAT3 regulation in vivo and in vitro. International Journal of Molecular Sciences, 2022, 23:8661.

2020

1. Man Yin#, Bingyu Ye#, Yifei Jin,Lin Liu, Yan Zhang, Ping Li, Yahao Wang, Ye Li, Yanping Han, Wenlong Shen*,Zhihu Zhao*. Changes in growth of Vibrio natriegens under simulated microgravity. Frontiers in Microbiology, 2020, 11: 2040.

2. Bingyu Ye#, Wenlong Shen#, ZhihuZhao*. ZNF143 is dynamically bound to a subset of its interphase sites duringmitosis. Biochemical and Biophysical Research Communications, 2020, 523(2): 293-298.

3. Bingyu Ye#, Ganggang Yang#, YuanmengLi, Chunyan Zhang*, Qiwen Wang*, Guoying Yu*. ZNF143 in chromatin looping and generegulation. Frontiers in Genetics, 2020,11: 338.

2019

1. Bingyu Ye#, Li Yin#, Qiwen Wang,Cunshuan Xu*. ACC1 is overexpressed in liver cancers and contributes to the proliferation of human hepatoma Hep G2 cells and the rat liver cell line BRL 3A. Molecular Medicine Reports, 2019, 19(5):3431-3440.

2. Qiwen Wang#, Bingyu Ye#, Ping Wang,Fenjie Yao, Chunyan Zhang*, Guoying Yu*. Overview of microRNA-199a regulationin cancer. Cancer Management and Research, 2019, 11:10327-12335.

3. Chunyan Zhang#, Bingyu Ye#, Jiaojiao Wei, Qiwen Wang*, Cunshuan Xu*, Guoying Yu*. MiR-199a-5p regulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway. Artificial Cells Nanomedicine and Biotechnology,2019, 47(1):4110-4118.

2018

1. Bingyu Ye, Wenlong Shen, Minglei Shi, Yan Zhang,Cunshuan Xu*, Zhihu Zhao*. Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models. PeerJ, 2018, 6: e5043.

2017

1. Qi Xie, Fengxu Fan, Wei Wei, Yang Liu, Zhongwei Xu, Linhui Zhai, Yingzi Qi, Bingyu Ye, Yao Zhang, Sumit Basu, Zhihu Zhao, Junzhu Wu*, Ping Xu*. Multi-omics analyses reveal metabolic alterations regulated by hepatitis B virus core protein in hepatocellular carcinoma cells. Scientific Reports,2017, 7: 41089.

2016

1. Bingyu Ye, Wenlong Shen, Dong Wang, Ping Li, Zhang Zhang,Minglei Shi, Yan Zhang, Feixiong Zhang*, Zhihu Zhao*. ZNF143 is involved in CTCF-mediated chromatin interactions by cooperation with cohesin and other partners. MolecularBiology, 2016, 50(3): 431-437.

2. Zhang Zhang, Yan Zhang, Minglei Shi, Bingyu Ye, Wenlong Shen, Ping Li, Lingyue Xing, Xiaopeng Zhang, Lihua Hou, Junjie Xu, Zhihu Zhao*,Wei Chen*. Anthrax susceptibility: human genetic polymorphisms modulating ANTXR2 expression. Toxins, 2016,8(1): 1.

2015

1. Wenlong Shen, Dong Wang, Bingyu Ye, Yan Zhang*, Zhihu Zhao*.GC3-biased gene domains in mammalian genomes. Bioinformatics, 2015, 31(19): 3081-3084.

2. Wenlong Shen, Dong Wang,Bingyu Ye, Yan Zhang*, Zhihu Zhao*. A possible role of Drosophila CTCF in mitotic bookmarking and maintaining chromatin domains during the cell cycle.Biological Research, 2015,48(1): 27.