張春艷，博士，講師。2018年12月獲新疆大學(xué)動(dòng)物學(xué)博士學(xué)位，2019年2月就職于河南師范大學(xué)生命科學(xué)學(xué)院生物工程系。主持河南省重點(diǎn)研發(fā)與推廣專項(xiàng)（科技攻關(guān)）、河南省高等學(xué)校重點(diǎn)科研項(xiàng)目計(jì)劃、河南師范大學(xué)培育基金青年項(xiàng)目、河南師范大學(xué)博士科研啟動(dòng)基金等，參與2項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目的研究工作，以第一作者或通訊作者在iScience, International Journal of Molecular Sciences, BMCGenomics, Cellular Signalling, Artif Cells Nanomed Biotechnol等SCI期刊上發(fā)表論文11篇。

肝再生和肝臟疾病中分子調(diào)控機(jī)制研究

1.miNRAs在肝再生和肝病中的作用及調(diào)控機(jī)制

2.鋅結(jié)合蛋白在肝再生和肝病中的作用及調(diào)控機(jī)制

3.線粒體和自噬在肝再生和肝病中作用機(jī)制

無(wú)

1.河南省重點(diǎn)研發(fā)與推廣專項(xiàng)(科技攻關(guān))，基于miR-125a-5p 激動(dòng)劑治療肝纖維化藥物靶點(diǎn)的篩選和應(yīng)用, 2022/01 -2023/12，主持

2. 河南師范大學(xué)國(guó)家級(jí)科研項(xiàng)目培育基金（理科），miR-125a-5p通過(guò)自噬調(diào)節(jié)肝再中肝細(xì)胞增殖的作用機(jī)制（20210390），2021/05 -2023/12，主持

3. 河南省高等學(xué)校重點(diǎn)科研項(xiàng)目計(jì)劃，miR-125a-5p通過(guò)自噬途徑調(diào)控肝細(xì)胞增殖的作用機(jī)制（20A180014），2020/01-2021/12，主持

4. 國(guó)家自然科學(xué)基金聯(lián)合基金，肝臟間皮干細(xì)胞的起源及其在肝再生中的作用研究（U1704182），2018/01-2020/12，參與

5. 國(guó)家自然科學(xué)基金青年基金項(xiàng)目，一個(gè)大鼠肝再生相關(guān)的新lncRNA（rLALR1）調(diào)節(jié)肝細(xì)胞增殖的作用及機(jī)理研究（31601038），2017/01-2019/12，參與

代表性論文：

1. Chunyan Zhang*, Caifang Sun, Yabin Zhao, Bingyu Ye, GuoYing Yu,*.Signaling pathways of liver regeneration: Biological mechanisms and implications. iScience.2023;27(1):108683.

2. Chunyan Zhang, YabinZhao, QiwenWang, Jianru Qin, Bingyu Ye, Cunshuan Xu, Guoying Yu*. Overexpression of miR-125a-5p Inhibits Hepatocyte Proliferation through the STAT3 RegulationIn Vivo and In Vitro, Int J Mol Sci, 2022, 23 (15): 8661.

3. Chunyan Zhang,Caifang Sun, Yabin Zhao, Qiwen Wang, Jianlin Guo, Bingyu Ye, Guoying Yu*;Overview of MicroRNAs as Diagnostic and Prognostic Biomarkers for High-Incidence Cancers in 2021, Int J Mol Sci, 2022 ,23(19):11389

4. Chunyan Zhang,Yabin Zhao, Mengli Yu, Jianru Qin, Bingyu Ye, Qiwen Wang*. Mitochondrial Dysfunction and Chronic Liver Disease, Curr Issues Mol Biol, 2022, 44(7):3156-3165.

5. Bingyu Ye#, WenlongShen#, Chunyan Zhang#, Mengli Yu, Xinru Ding, Man Yin, Yahao Wang,Xinjie Guo, Ge Bai, Kailin Lin, Shu Shi, Ping Li, Yan Zhang, Guoying Yu*, ZhihuZhao*. The role of ZNF143 overexpression in rat liver cell proliferation. BMC Genomics, 2022, 23: 483.

6. Qiwen Wang, Weixia Liu,Gaopeng Liu, Pan Li, Xueqiang Guo, Chunyan Zhang*. AMPK-mTOR-ULK1-mediated autophagy protects carbon tetrachloride -induced acute hepatic failure by inhibiting p21 in rats.J Toxicol Pathol. 2021;34(1): 73–82.

7. Chunyan Zhang, Bingyu Ye, Jiaojiao Wei, Qiwen Wang, Cunshuan Xu, Guoying Yu. MiR-199a-5pregulates rat liver regeneration and hepatocyte proliferation by targeting TNF-α/TNFR1/TRADD/CASPASE8/CASPASE3 signalling pathway.Artif Cells Nanomed Biotechnol. 2019; 47(1):4110-4118.

8. Qiwen Wang#, BingyuYe#, Ping Wang, Fenjie Yao, Chunyan Zhang*, Guoying Yu*. Overview of microRNA-199a regulationin cancer. Cancer Management and Research, 2019,11:10327-12335.

9. Chunyan Zhang,Cuifang Chang, Hang Gao, Qiwen Wang, Fuchun Zhang, Cunshuan Xu. MiR-429 regulates rat liver regeneration and hepatocyte proliferation by targeting JUN/MYC/BCL2/CCND1 signaling pathway. Cell Signal. 2018; 50 :80-89.

10. Chunyan Zhang, Cuifang Chang, Weiming Zhao, Hang Gao, Qiwen Wang, Deming Li, Fuchun Zhang, Shifu Zhang, Cunshuan Xu. The novel protein C9orf116 promotes rat liver cellline BRL-3A proliferation. PLoS One. 2017; 12(7):e0180607.

11. Chunyan Zhang, Cuifang Chang, Deming Li, Fuchun Zhang, Cunshuan Xu. The novel protein C3orf43 accelerates hepatocyte proliferation. Cell Mol Biol Lett. 2017; 22:21.