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          楊鈞棠

          發(fā)布時(shí)間:2019-11-15






          姓   名:   楊鈞棠

          職   稱:   講師

          辦公電話:   

          電子郵箱:  2018207@htu.edu.cn










          個(gè)人簡(jiǎn)介:

             博士畢業(yè)于第三軍醫(yī)大學(xué),博士期間主要從事肺癌和乳腺癌發(fā)病機(jī)制研究工作,發(fā)現(xiàn)了Wnt/β-catenin通路在肺癌中的新的調(diào)控機(jī)制,該通路在胚胎發(fā)育,腫瘤發(fā)生以及肺纖維化中發(fā)揮關(guān)鍵功能。博士畢業(yè)后于美國(guó)希望城國(guó)家醫(yī)學(xué)中心從事DNA損傷修復(fù)與肺癌發(fā)生關(guān)系的研究。2018年7月進(jìn)入河南師范大學(xué)生命科學(xué)學(xué)院工作,從事肺纖維化發(fā)病機(jī)理的研究。目前總計(jì)發(fā)表SCI論文10篇,其中5分以上5篇,第一作者4篇(>5分1篇),共同第一作者1篇(>5分)。

          研究領(lǐng)域:

              肺纖維化發(fā)病機(jī)制研究。

          主要學(xué)術(shù)及社會(huì)兼職:

              無(wú)

          主持或參加科研項(xiàng)目情況:

          1. 河南省高等學(xué)校重點(diǎn)科研項(xiàng)目(20A310006)       2019-2021    主持

          2. 河南師范大學(xué)博士科研啟動(dòng)基金(5101049170182) 2019-2022    主持

          3. 河南省自然科學(xué)基金 (202300410227)             2021-2022    主持

          學(xué)術(shù)成果:

          1. Juntang Yang, Xin Pan,Lan Wang, Guoying Yu.Alveolar cells under mechanical stressed niche:critical contributors to pulmonary fibrosis. Molecular Medicine(IF=4.09) (2020) 26:95

          2. Yang JT, Wang Lan, Pan Xin, Zhao Weiming, Zhang Xinsheng, Yu Guoying. Mechanical Stress Contribute to Pulmonary Fibrosis viaMitochondria! Damage of Type II Alveolar Epithelial Cells. American journal of respiratory and critical care medicine. (IF=17.452) (2020)201

          3. Fei Han, Li Yin, Xiao Jiang, Xi Zhang, Ning Zhang, Jun-tang Yang,Wei-ming Ouyang, Xiang-lin Hao, Wen-bin Liu, Yong-sheng Huang, Hong-qiang Chen, Fei Gao,Zhong-tai Li, Qiao-nan Guo, Jia Cao, Jin-yi Liu, Identification of SRY-box 30as an age-related essential gatekeeper for male germ-cell meiosis and differentiation. Aging Cell (IF=7.238) 2021;00:e13343

          4. Tang CZ#, Yang JT#(共同第一), Liu QH, Wang YR, Wang WS: Up-regulated miR-192-5p expression rescues cognitive impairment and restores neural function in mice with depression via the Fbln2-mediated TGF-beta1 signaling pathway. FASEB journal(IF=5.595) : official publication of the Federation of American Societies for Experimental Biology 2019, 33(1):606-618.

          5. Tang CZ, Zhang DF, Yang JT,Liu QH, Wang YR, Wang WS. Overexpression of microRNA-301b accelerate shippocampal microglia activation and cognitive impairment in mice with depressive-like behavior through the NF-κB signaling pathway. Cell Death Dis (IF=5.638). 2019 Apr 8;10(4):316. doi: 10.1038/s41419-019-1522-4.

          6.Han F, Liu WB, Li JJ, Zhang MQ, Yang JT, Zhang X, Hao XL, YinL, Mao CY, Jiang X et al: SOX30 is a prognostic biomarker and chemotherapeutic indicator for advanced-stage ovarian cancer. Endocrine-related cancer(IF=5.331) 2019.

          7. Han F, Liu WB, Shi XY, Yang JT, Zhang X, Li ZM,Jiang X, Yin L, Li JJ, Huang CS et al: SOX30 Inhibits Tumor Metastasis through Attenuating Wnt-Signaling via Transcriptional and Posttranslational Regulation of beta-Catenin in Lung Cancer. EBioMedicine (IF=6.138) 2018, 31:253-266.

          8. Yang J, Han F, Liu W, Chen H, Hao X, Jiang X, Yin L,Huang Y, Cao J, Zhang H et al: ALX4, an epigenetically down regulated tumor suppressor, inhibits breast cancer progression by interfering Wnt/beta-catenin pathway. Journal of experimental & clinical cancer research : CR(IF=6.217) 2017, 36(1):170.

          9. Yang J, Han F, Liu W, Zhang M, Huang Y, Hao X, Jiang X, Yin L, Chen H, Cao J et al: LHX6, An Independent Prognostic Factor, Inhibits Lung Adenocarcinoma Progression through Transcriptional Silencing ofbeta-catenin. Journal of Cancer 2017(IF=3.2),8(13):2561-2574.

          10. Yang J, Wang R,Liu B, Xue Q, Zhong M, Zeng H, Zhang H: Kinetic analysis of bypass of abasicsite by the catalytic core of yeast DNA polymerase eta. MutationResearch/Fundamental and Molecular Mechanisms of Mutagenesis (IF=2.5) 2015, 779:134-143.