常翠芳，1982年2月生，畢業(yè)于新疆大學，博士、副教授，碩士生導師。2011年博士畢業(yè)后就職于河南師范大學生命科學學院，主要從事細胞生物學和分子生物學的教學和科研工作。自工作以來，主持國家自然科學基金項目、河南省自然科學基金項目、教育廳項目、校級項目等，并參與完成多項國家級重大項目，在J Cell Physiol、Cell Biochem Funct等期刊發(fā)表論文50多篇，參編的《大鼠肝再生的功能基因組學研究》專著獲2010年教育部自然科學二等獎。

肝纖維化、肝再生的分子調(diào)控機理

中國細胞生物學學會會員

河南省實驗動物學學會理事

1.國家自然科學基金項目：絲氨酸蛋白酶抑制劑III對大鼠再生肝的肝細胞增殖調(diào)控機理研究，主持

2.河南省自然科學基金項目：絲氨酸蛋白酶抑制劑I和III調(diào)控再生肝的肝細胞機理研究，主持

3.河南省自然科學基金項目：肝再生相關(guān)孤兒受體GPR50調(diào)控肝細胞增殖的蛋白組學及其作用機制研究，主持

4.河南省高等學校重點科研項目：SPINK1 調(diào)控大鼠正常肝細胞和肝癌細胞增殖機理的比較研究，主持

5.河南省高等學校重點科研項目：干擾SPINK1對肝纖維化的影響及調(diào)控機制研究，主持

6.國家自然科學基金項目：一個大鼠肝再生相關(guān)的新lncRNA（rLALR1）調(diào)節(jié)肝細胞增殖的作用及機理研究，參與

7.國家973計劃前期研究專項：大鼠肝再生的蛋白質(zhì)學研究，參與

8.國家973計劃前期研究專項：肝臟損傷修復與再生機制的蛋白質(zhì)組學基礎(chǔ)研究，參與

代表性論文： 

1. Chang CF, Wang DL,Xi LL, Guo XQ, Wang G,P Yu GY. The orphan GPR50 receptor interacting with TβRIinduces G1/S-phase cell cycle arrest via Smad3-p27/p21 in BRL-3A cells. BiochemPharmacol. 2022, 202:115117.

2.Chang CF, Xie JJ, Yang QD, Yang J, Luo YR, Xi LL, Guo JL, Yang GG, Jin W, Wang GP. Serine peptidase inhibitor Kazal type III (SPINK3) promotes BRL‐3A cell proliferation by targeting the PI3K–AKT signaling pathway. Journal of Cellular Physiology. 2020, 235(3): 2209-2219.

3.Li  JJ, Ye CL, Chang CF. Comparative  transcriptomics analysis revealing flower trichome development during flower development in two Lonicera japonica Thunb. cultivars using RNA-seq. BMC  Plant Biol. 2020, 20(1):341.

4.Wang  GP, Chu PP, Chen M, Cheng LY, Zhao CC, Chen SS, Li XF, Yang GG, Chang CF. Osteopontin promotes rat  hepatocyte proliferation both in vitro and in vivo. Artificial Cells, Nanomedicine and Biotechnology. 2019, 47(1): 3745-3757.

5.Wang GP; Guo XQ, Cheng LY, Chu PP, Chen M, Chen YH, Chang CF. An integrated analysis of the circRNA-miRNA-mRNA  network reveals novel insights into pot ential mechanisms of cell proliferation during liver regeneration, Artificial Cells, Nanomedicine and  Biotechnology. 2019, 47(1): 3873-3884.

6.Chang CF, Zhao WM, Luo YR, Xi LL, Chen SS, Zhao CC, Wang GP, Guo JL, Xu CS. Serine peptidase inhibitor Kazal type I (SPINK1) promotes BRL-3A cell proliferation via p38, ERK,and JNK pathways. Cell Biochem Funct. 2017, 35(6):339-348.

7.Chang CF, Niu ZP, Gu NN,  Zhao WM, Wang GP, Jia YF, Li DM, Xu CS. Analysis of the ways and methods of signaling pathways in regulating cell cycle of NIH3T3 at transcriptional level. BMC Cell Biology, 2015, 16:25.

8.Chang CF, Xu CS. Transcriptome atlas of aromatic amino acid family metabolism-related genes in eight liver cell types uncovers the corresponding metabolic pathways in rat liver regeneration. Int J Biochem Cell Biol, 2010, 42(10):1708-1716.

9.Xu CS, Chang CF. Expression profiles of the genes associated with metabolism and transport of amino acids and their derivatives in rat liver regeneration. Amino Acids. 2008, 34(1):91-102.

10.Chang CF, Yang J, Li XF, Zhao WM, Li Y, Guo PJ, Wang GP, Xu CS. Thrombopoietin signaling pathway regulates the hepatocytes activation in rat liver regeneration. Biochem  Genet, 2015, 53(9-10): 244-259.

11.Chang CF, Yang J, Li XF, Zhao WM, Chen SS, Wang GP, Xu CS. SPINK3: A novel growth factor that promotes rat liver regeneration. Molecular Biology, 2016, 50(3):398-404.

12.Chang CF, Zhao WM, Yang J, Li MH, Zhou Y, Xu CS. Study on activity of the signaling pathways regulating hepatocyte differentiation during rat liver regeneration. Anim Cells Syst, 2014, 18(6): 416-424.

13.Chang CF, Xu CS. Transcriptome atlas of glutamine family amino acid metabolism-related genes in eight regenerating liver cell types. Cell Biol Int, 2010, 34(12):1189-1198.

14.Chang CF, Fan JY, Zhang FC, Ma J, Xu CS. Transcriptome atlas of eight liver cell types uncovers effects of histidine catabolites on rat liver regeneration. J Genet, 2010, 89(4):425-436.

15.Chang CF, Yang J, Zhao WM, Li Y, Guo PJ, Li MH, Zhou Y, Xu CS. Gene expression profiling analysis of  5-hydroxytryptamine signaling pathway in rat regenerating liver and different types of liver cells. Genet Mol Res, 2015, 14(2): 3409-3420.

16.Chang CF, Zhao WM, Mei JX, Zhou Y, Pan CY, Xu TT, Xu CS. Branches of NF-κb signaling pathway regulate  hepatocyte proliferation in rat liver regeneration. Genet Mol Res, 2015,14 (3):7643-7654.

17.Geng XF, Chang CF, Zang XY, Sun JY, Li PF, Guo JL, Xu CS. Integrative proteomic and microRNA analysis of the priming phase during rat liver regeneration. Gene, 2016, 575(2 Pt 1):224-232.

18.Ding Y, Chang CF, Niu ZP, Dai KQ, Geng  XF, Li DM, Guo JL, Xu CS. Overexpression of Transcription Factor Foxa2 and Hnf1α induced Rat Bone Mesenchymal Stem Cells into Hepatocyte. Cytotechnology, 2016, 68(5):2037-2047.

專利成果： 

1.基于OPN基因誘導的肝細胞體外增殖方法（專利號: ZL201510773582.1）

2.一種表達人血清白蛋白的質(zhì)粒和重組菌以及它們的應用(ZL 201310078906.0)

3.表達人血清白蛋白的質(zhì)粒和重組菌以及它們的應用(ZL 201310078280.3)

4 一種抗癌藥物及其應用（ZL 2018 10968867.4）