王蘭，女，教授，博士生導(dǎo)師。國(guó)家肺纖維化生物學(xué)過(guò)程及防控學(xué)科創(chuàng)新引智基地（111計(jì)劃）秘書(shū)，河南省器官纖維化杰出外籍科學(xué)家工作室負(fù)責(zé)人，中國(guó)生物物理學(xué)會(huì)表型組分會(huì)委員，河南省生物化學(xué)與分子生物學(xué)學(xué)會(huì)副理事長(zhǎng)，河南省藥學(xué)會(huì)中藥資源委員會(huì)委員，河南省藥學(xué)會(huì)天然產(chǎn)物委員會(huì)委員，國(guó)際期刊《Fibrosis》副主編。主要從事肺纖維化生物標(biāo)志物和甲狀腺激素調(diào)控肺纖維化的代謝穩(wěn)態(tài)研究。

2011年6月博士畢業(yè)于韓國(guó)江原大學(xué)醫(yī)生命學(xué)院，獲得生物醫(yī)學(xué)博士學(xué)位。2006.10－2007.10間，作為訪問(wèn)學(xué)者到丹麥哥本哈根大學(xué)生命科學(xué)學(xué)院合作研究，2016.7－2017.7 在美國(guó)華盛頓州立大學(xué)藥學(xué)院訪問(wèn)學(xué)者，主要從事端粒酶基因的表觀遺傳調(diào)控研究, 2017.12--2019.08，復(fù)旦大學(xué)生科院訪問(wèn)研究，主要從事多組學(xué)解析疾病機(jī)理研究。目前主持及參與國(guó)家重點(diǎn)研發(fā)專項(xiàng)、國(guó)家自然基金、河南省重點(diǎn)研發(fā)專項(xiàng)、河南省國(guó)際科技合作項(xiàng)目、國(guó)家虛擬仿真實(shí)驗(yàn)教學(xué)一流課程、河南省優(yōu)質(zhì)資源課-雙語(yǔ)教學(xué)示范課等項(xiàng)目10余項(xiàng)，在Am J Respir Crit Care Med 、Molecular & CellularProteomics等國(guó)際期刊發(fā)表學(xué)術(shù)論文40余篇，發(fā)明授權(quán)國(guó)家專利2項(xiàng)，受理3項(xiàng)，主編《肺纖維化小鼠模型構(gòu)建，診斷及治療》、參編《生物化學(xué)》等教材6部。

多組學(xué)解析疾病機(jī)理

肺纖維化生物標(biāo)志物

甲狀腺激素調(diào)控肺纖維化的代謝穩(wěn)態(tài)

河南省生物化學(xué)與分子生物學(xué)學(xué)會(huì)副理事長(zhǎng)

國(guó)際期刊《Fibrosis》副主編

中國(guó)生物物理學(xué)會(huì)表型組分會(huì)委員

河南省藥學(xué)會(huì)中藥資源委員會(huì)委員

河南省藥學(xué)會(huì)天然產(chǎn)物委員會(huì)委員

1、甲狀腺激素對(duì)肺纖維化的治療作用與機(jī)理研究。國(guó)家重點(diǎn)研發(fā)計(jì)劃任務(wù)負(fù)責(zé)人

2、基于S蛋白受體結(jié)合結(jié)構(gòu)域（RBD）的新冠肺炎病毒疫苗研發(fā)及肺纖維化控制。高端外國(guó)專家引進(jìn)計(jì)劃新冠肺炎防控專項(xiàng)計(jì)劃

3、肺纖維化治療新藥研發(fā)。河南省重點(diǎn)研發(fā)計(jì)劃。第一參與人

4、肺纖維化新藥GC-1研發(fā)。新鄉(xiāng)市重大科技創(chuàng)新專項(xiàng)。第一參與人

5、器官纖維化杰出外籍科學(xué)家工作室。河南省外國(guó)專家項(xiàng)目。負(fù)責(zé)人

6、特發(fā)性肺纖維化診斷血清標(biāo)志物的確立。河南省科技攻關(guān)項(xiàng)目，主持

7、多組學(xué)解析甲狀腺激素調(diào)控肺纖維化的機(jī)制。河南省國(guó)際科技合作，主持

8、肺纖維化血清標(biāo)志物的研發(fā)。橫向合作。主持

9、植物源性抗菌肽生物活性研究。河南省重點(diǎn)科技攻關(guān)項(xiàng)目。主持

10、火炬樹(shù)果實(shí)有效成分抑制結(jié)腸癌機(jī)理研究。河南省科技攻關(guān)項(xiàng)目。主持

11、肺纖維化小鼠模型構(gòu)建、診斷及治療虛擬仿真實(shí)驗(yàn)。國(guó)家級(jí)一流課程

12、《高級(jí)生物化學(xué)》河南省優(yōu)質(zhì)資源課雙語(yǔ)教學(xué)示范課，負(fù)責(zé)人

代表性論文：

1. Lan Wang;Minghui Zhu; Yan Li; Peishuo Yan; Zhongzheng Li; Xiuping Chen; Juntang Yang;Xin Pan; Huabin Zhao; Shenghui Wang; Hongmei Yuan; Mengxia Zhao; Xiaogang Sun;Ruyan Wan; Fei Li; Xiaobo Wang; Hongtao Yu; Ivan Rosas; Chen Ding; Guoying Yu*.Serum proteomics identify biomarkers associated with the pathogenesis of idiopathic pulmonary fibrosis, Molecular & Cellular Proteomics, 2023

2. Lan Wang, Hongmei Yuan, Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li,Huabin Zhao, Shenghui Wang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan,Ivan Rosas, Guoying Yu*. ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis.BBA - Molecular Basis of Disease 1870(2024) 166960

3. Lan Wang, Wenyu Zhao, Cong Xia, Shuaichen Ma, Zhongzheng Li, Ningdan Wang, Linke Ding, YaxuanWang, Lianhui Cheng, Huibing Liu, Juntang Yang, Yajun Li, Ivan Rosas,Guoying Yu*. TRIOBP modulates β?cateninsignaling by regulation of miR?29b in idiopathic pulmonary fibrosis. Cellular and Molecular Life Sciences (2024)81:13.

4. Lan Wang;Zhongzheng Li; Ruyan Wan; Xin Pan; Bin Li; Huabin Zhao; Juntang Yang; Weiming Zhao; Shenghui Wang; Qiwen Wang; Peishuo Yan; Chi Ma; Hongmei Yuan; Ivan Rosas;Chen Ding; Baofa Sun; Guoying Yu*. Single-cell RNA-seq provides new insights into therapeutic roles of thyroid hormone in the idiopathic pulmonary fibrosis,Am J Respir Cell Mol Biol, 2023 Oct;69(4):456-469.

5. Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang,Juntang Yang, Yajun Li, Ivan Rosas, Lan Wang* and Guoying Yu*.Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly. Respiratory Research (2023) 24:318.https://doi.org/10.1186/s12931-023-02633

6.Ruyan Wan, Lan Wang, Miaomiao Zhu, Wenwen Li,Yudi Duan and Guoying Yu*. Cellular Senescence: A Troy Horse in Pulmonary Fibrosis. Int. J. Mol. Sci. 2023, 24(22), 16410.

7.Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu,Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu*. ADRB2 inhibition combined with antioxidant treatment alleviates lungfibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts. Cell Death Discovery

8.Zhao H, Wang J, Li Z, Wang S, Yu G and Wang Lan*.Identification ferroptosis-related hub genes and diagnostic model inAlzheimer’s disease. Frontiers in Molecular Neuroscience. 16:1280639.

9.Weiming Zhao; Lan Wang; Juntang Yang; Xinyu Chen; Xiaoshu Guo; Kai Xu; Ningdan Wang; Wenyu Zhao; Cong Xia; Hui Lian; Ivan Rosas; Guoying Yu ; Endothelial cell-derived MMP19 promotes pulmonary fibrosisby inducing E(nd)MT and monocyte infiltration, Cell Communication and Signaling, 2023, 21(56): 1-17

10.Weiming Zhao; Lan Wang; Yaxuan Wang; Hongmei Yuan; Mengxia Zhao; Hui Lian; Shuaichen Ma; Kai Xu; Zhongzheng Li; Guoying Yu*. Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis, International Journal of Molecular Sciences, 2023, 24(10):8749-8766.

11.Zhongzheng Li, Liu Xin, Lan Wang, Huabin Zhao, ShenghuiWang, Guoying Yu, Depei Wu, Jianhong Chu, Jingjing Han. Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals RNA N6-methyladenosine modification associated with prognosis and drug resistance in acute myeloid leukemia. Front.Immunol. Volume 14 - 2023.

12. Zhongzheng Li; Shenghui Wang; Huabin Zhao; Peishuo Yan; Hongmei Yuan;Mengxia Zhao; Ruyan Wan; Guoying Yu; Lan Wang*. Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis, Scientific Reports, 2023,13(1): 1-15

13. Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li,Ivan Rosas, Lan Wang* and Guoying Yu*.Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly.Respiratory Research (2023) 24:318.

14. Lan Wang; Wenyu Zhao; Cong Xia; Zhongzheng Li;Weiming Zhao; Kai Xu; Ningdan Wang; Hui Lian; Ivan O. Rosas; Guoying Yu ; TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 inIPF, Int. J. Mol. Sci., 2022, 23(24):15705

15.Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan, Weiming Zhao,Xiaoshu Guo, Xin Pan, Juntang Yang, Ivan Rosas and Guoying Yu*. Fenbendazole attenuates bleomycin-Induced pulmonary fibrosis in mice via suppression of fibroblast-to-myofibroblast differentiation. Int. J. Mol. Sci. 2022,23,14088.

16. Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu*. Inhibition of MAD2L1 mediates pulmonary fibrosis through impairment of mitochondrial function and induction of cell senescence. Canadian Respiratory Journal, 2022, Article ID 9663354, 13

17. Juntang Yang; Chenxi Liang; Lulu Liu; Lan Wang; Guoying Yu ;High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters, Biomolecules,2023

18.Wang Y, Gong W,Zhou H, Hu Y, Wang L, Shen Y, Yu Guoying, Cao J. A novel miRNA from egg-derived exosomes of Schistosoma japonicum promotes liver fibrosis in murine schistosomiasis. Front. Immunol., 27 April 2022

19.Lan Wang, Zhongzheng Li, Huabin Zhao, Guoying Yu. Thyroid Hormone Signal Attenuates Pulmonary Fibrosis Through Cell Interaction and Communication in Bleomycin-Induced Mouse Lung. Am J Respir Crit Care Med 2022;205:A1963

20.Lan Wang, Zhongzheng Li, Huabin Zhao, Guoying Yu. A weighted gene co-expression network analysis (WGCNA)identifies the key genes associated with IPF. Am J Respir CritCare Med 2021;203: A4641

21.Yang J, Pan X, Wang L, Yu Guoying*.Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis. Molecular medicine 2020, 26(1).

22.Lan Wang, Zhongzheng Li, Huabin Zhao, Guoying Yu. Serum proteome profiling discovers novel proteinsassociated with idiopathic pulmonary fibrosis. Am J Respir Crit CareMed 2020;201: A4021

23.Lan Wang，Ming Lu Xu，Ling Xin，Chi Ma，Guoying Yu. Oxidative stress inducedapoptosis mediated anticancer activity of Rhus typhina fruits extract inhuman colon cancer. Medicinal Chemistry Research, 2019, (28), 6, 917–925

24.Lan Wang, Ming Lu Xu, Jie Liu , You Wang ,Jian He Hu, Myeong-Hyeon Wang. Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages. Nutrition Research and Practice，2015;9(6):579-585

25. Yong-Chao Li, Lan Wang, Ben-zhai Hai and Ming-Lu Xu. Effect of Various Treatment Methods on the Bisphenol A Concentration in Edible Mushroom Segments during Cultivation.Advance Journal of Food Science and Technology 13(1): 40-48, 2017

26. Lan Wang, Ming Lu Xu, Jian He Hu, S?ren K.Rasmussen, Myeong-Hyeon Wang. Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells - Involvement of ROS generation and polyamine depletion. Food and Chemical Toxicology 2011, 49:149-154.

27. Lan Wang, MingLu Xu, Li Jie Guo , Lin Song Wang. Antioxidant activities and phenolic compounds of various extracts of Rhus typhina fruits and leaves.Advance Journal of Food Science and Technology 2015 ,7(4): 223-229.

28. Lan Wang, Hee Jeong Son, Ming-Lu Xu, Jian-He Hu, and Myeong-Hyeon Wang*. Anti-inflammatory and anticancer properties of dichloromethane and butanol fractions from the stem bark of Broussonetia papyrifera. Journal Korean Social Application Biology Chemistry 2010, 53(3):297-303.

29.Lan Wang, Ming Lu Xu, S?ren K. Rasmussen ,Myeong-Hyeon Wang*. Vomifoliol 9-O-α-arabinofuranosyl (1→6)-β-D-glucopyranoside from the leaves of Diospyros Kaki stimulates the glucose uptake in HepG2 and 3T3-L1 cells. Carbohydrate Research. 2011,346:1212-1216.

30. Lan Wang, Gui-Fang Xu, Xiao-Xia Liu, Ai-Xia Chang, Ming-Lu Xu, Amal Kumar Ghimeray, Jing-Pei Piao and DongHa Cho*. In vitro antioxidant properties and induced G2/M arrest in HT-29 cells of dichloromethane fraction from Liriodendron tulipifera. Journal of Medicinal Plants Research 2012, 6(3):424-432.  

31. Ming-Lu Xu，Lan Wang, Gui-Fang Xu, Jian-He Hu, and Myeong-Hyeon Wang*. Antioxidant and anti-proliferative activities of different solvent fractions from methanol extracts of Sparganiun stoloniferum. Horticulture Environment and Biotechnology. 2010, 51(6):539-544.

32. Li Wang, Lan Wang, Fang-Jun Li, Lin-Song Wang*, and Myeong-Hyeon Wang Modulation of endogenous peroxidase by exogenous peroxidase in chinese red radish seedling. Hort. Environ. Biotechnol.2011, 52(5):448-454.

33. HuanLiu, Lan Wang, and Myeong-Hyeon Wang*. Antioxidant and nitricoxide release inhibition activities of methanolic extract from Many flower Glorybower.Horticulture, Environment, and Biotechnology. 2011, 52(3):1-6.  

34. Ming-Lu Xu, Lan Wang, Jian-He Hu, Soek Ki Lee, and Myeong-Hyeon Wang*. Antioxidant activities and related polyphenolic constituents of the methanol extract fractions from Broussonetia papyrifera stem bark and wood. Food Sci. Biotechnol.2010, 19(3):677-682.  

35. Xiao Xia Liu*, Lan Wang, Yu Jie Wang, Li Ling Cai.D-glucose Enhanced 5-Aminolevulinic Acid Production in Recombinant Escherichia coli Culture. 2010, 160:822-830. 

36. Ming-Lu Xu, Lan Wang, Jian-He Hu, Soek Ki Lee, andMyeong-Hyeon Wang*. Antioxidant activities and related polyphenolicconstituents of the methanol extract fractions from Broussonetia papyrifera stem bark and wood.Food Sci. Biothechnol. 2010, 19(3): 677-682.

37. Ming-Lu Xu, Lan Wang and Myeong-Hyeon Wang*. TheAntioxidant and Anticancer Effects of MeOH Extract of Liriodendron tulipifera. Korean J. Plant Res. 2011, 24(1):23-29.

38. Ming-Lu Xu, Lan Wang, Gui-Fang Xu and Myeong-Hyeon Wang*.Antidiabetes and Angiotensin Converting Enzyme Inhibitory Activity of Sonchus asper (L) Hill Extract. Kor. J. Pharmacogn. 2011, 42(1):61-67.

39. 朱明慧，萬(wàn)汝燕，李飛，王曉博，于洪濤，王蘭，余國(guó)營(yíng)。特發(fā)性肺纖維化血清生物指示物的研究。國(guó)際呼吸雜志，2020年12月第40卷第23期，1801-05

40. 邢雙濤，馮世杰，張一凡，王蘭，余國(guó)營(yíng)。不同運(yùn)動(dòng)方式對(duì)哮喘患兒肺功能影響的網(wǎng)狀Meta分析.[J].河南師范大學(xué)學(xué)報(bào)(自然科學(xué)版),2023（02）

發(fā)明專利：

1.王蘭;余國(guó)營(yíng)。特發(fā)性肺纖維化疾病血液診斷標(biāo)志物 CBRI 及其在制備診斷或預(yù)后工具中的應(yīng)用, 2020-11-05, 中國(guó), 202011218094.1 (專利)

2.王蘭;閆培碩; 余國(guó)營(yíng)。特發(fā)性肺纖維化疾病診斷標(biāo)志物 CCT6A 及其制備診斷或預(yù)后工具中的應(yīng)用,2020-11-5, 中國(guó), 202011218095.6 (專利)

3.王蘭; 余國(guó)營(yíng)。特發(fā)性肺纖維化疾病診斷標(biāo)志物及其制備診斷或預(yù)后工具中的應(yīng)用, 2019-12-13, 中國(guó), 201911277110.1 (專利)

4.王蘭，邱宗波，許明錄，常愛(ài)霞，周春娥, 李建軍。一種從火炬樹(shù)果實(shí)中提取木犀草素和木犀草素-7-O-β-D-吡喃葡萄糖苷的方法（ZL201510050991.9），國(guó)家發(fā)明專利，2017

5.胡建和，杭柏林，王青，付登峰，許明錄，王蘭，尚田田，徐彥召，劉興友?？咕腘X-16及其制備方法和利用（ZL201110168592.4）,國(guó)家發(fā)明專利，2013

著作：

1.《肺纖維化小鼠模型構(gòu)建、診斷及治療》數(shù)字化教材，高等教育出版社，主編，2022

2.《動(dòng)物源性抗菌肽》，科學(xué)出版社，副主編，2015年

3.《基因工程》，科學(xué)出版社，參編，2012年

4.《生物化學(xué)》，科學(xué)出版社，參編，2011，2016年

5.《生物化學(xué)習(xí)題集》，科學(xué)出版社，參編，2012年