王海磊，男，1978年9月，河南睢縣人，漢族，中共黨員，本科畢業(yè)于河南師范大學(xué)生物技術(shù)專業(yè)，中國科學(xué)院生物物理學(xué)博士，河南師范大學(xué)特聘教授，河南省高?？萍紕?chuàng)新人才，新加坡南洋理工大學(xué)訪問學(xué)者。申請國家發(fā)明專利15項。在Biotechnology Bioengineering、Applied Environmental Microbiology、Biotechnology for Biofuels等國內(nèi)外期刊上發(fā)表SCI論文60余篇。Biotechnology Bioengineering、Environmental Science Technology、Water Research、Biotechnology Progress、Bioresource Technology、Biochemical Engineering Journal、Enzyme and microbial technology、Process Biochemistry、Journal of Applied Microbiology等多個國際期刊審稿專家。

1. 微生物間相互作用機制；

2. 創(chuàng)新藥物、新型食品添加劑的微生物發(fā)酵與產(chǎn)業(yè)化;

3. 腸道細(xì)菌的精確編輯技術(shù)。

1. 中國科學(xué)院湖北產(chǎn)業(yè)創(chuàng)新及育成中心生物技術(shù)工程化中心技術(shù)委員會委員；

2. 功能微生物綠色轉(zhuǎn)化河南省工程實驗室、資源微生物與功能分子河南省重點實驗室副主任；

3. 中國微生物學(xué)會會員，河南省微生物學(xué)會常務(wù)理事。

    承擔(dān)3項國家自然科學(xué)基金項目[絲狀真菌Phanerochaete sp. HSD促進好氧活性污泥快速顆?；臋C理. 2011.1-2013.12 (No.51008119）；一種青霉紅色素的二元發(fā)酵機制研究.2015.1-2017.12（U1404301）；Phanerochaete chrysosporium 生物強化削減豬糞堆肥中四環(huán)素抗性基因的機制.2017.01-2019.12(U160411067)]. 此外主持河南師范大學(xué)特聘教授啟動基金（2012年），河南省高?？萍紕?chuàng)新人才支持計劃項目[黃孢原毛平革菌厚垣孢子化機制研究，18HASTIT039]; 河南省青年骨干教師項目[2015.01-2017.12, 基于基因水平的Phanerochaete chrysosporium厚垣孢子的誘導(dǎo)機制研究(2015GGJS-091)]及企業(yè)橫向課題等項目多項。

代表性論文：

1．Li Ping, Jing Ruxian, Jia Pei, Li Zhuoya, Liu Guosheng, Wang Zhenyu, Wang Hailei*.Whole-cell biosynthesis of cytarabine by an unnecessary protein-reduced Escherichia coli that coexpresses purineand uracil phosphorylase. Biotechnology Bioengineering 2022, DOI: 10.1002/bit.28098

2. Yi Li, Xiaomin Wu, Xiaobing Jiang, LeiLiu, Hailei Wang*. Algicidal activity of Aspergillus niger induced by calciumion as signal molecule on Microcystis aeruginosa. Algal Research 2021,60: 102536

3.Liu L, Li H, Liu Y, Li Y, Wang H*. Whole Transcriptome analysis provides insights into the molecular mechanisms of chlamydospore-like cell formation in Phanerochaete chrysosporium. Front Microbiol. 2020, 11: 527389.

4.Jiang X, Ren S, Geng Y, Yu T, Li Y, Liu L, Liu G, Wang H*, Shi L. The sugoperon involves in resistance to quaternary ammonium compounds in Listeria monocytogenes EGD-e. Applied Microbiology Biotechnology 2020, 104(16): 7093-7104.

5. Xiaobing Jiang, Yimin Geng, Siyu Ren, Tao Yu, Yi Li,Guosheng Liu, Hailei Wang*, Hecheng Meng, Lei Shi. The VirAB-VirSR-AnrAB multi-component system involves in resistance of Listeria monocytogenes EGD-e to cephalosporins, bacitracin, nisin,benzalkonium chloride and ethidium bromide. Applied Environmental Microbiology 2019, 85(20): e01470-19.

6. Lei Liu，Jie Song，Yi Li，Ping Li，Hailei Wang*.Robust and cost-saving static solid cultivation method for lipid production using the chlamydospores of Phanerochaete chrysosporium. Biotechnology for Biofuels 2019, 12:123

7. Yi Li, Zhiyu Zhang, Yingxing Duan, Hailei Wang*. The effect of recycling culture medium after harvesting of Chlorella vulgaris biomass by flocculating bacteria on microalgal growth and the functionary mechanism. Bioresource Technology 2019, 280:188-198.

8. Kun Zhang, Xinxin Lu, Yi Li, Xiaobing Jiang, Lei Liu, Hailei Wang*. New technologies provide more metabolic engineering strategies for bioethanol production in Zymomonas mobilis. Applied Microbiology Biotechnology 2019,103: 2087–2099.

9. Yi Li, Xu Yanting,Zheng Tianling,Wang Hailei*. Aminoacids in cell wall of Gram-positive bacterium Micrococcus sp. hsn08 with flocculation activity on Chlorella vulgaris biomass. Bioresource Technology 2018,249:417-424

10.Yi Li, Xu Yanting, Lei Liu, Ping Li, Yue Yan, Tong Chen, Zheng Tianling, Wang Hailei*. Flocculation mechanism of Aspergillus niger on havesting of Chlorella vulgaris biomass. Algal Research 2017, 25: 402-412

11. Yi Li, Xu Yanting, Zheng Tianling, Wang Hailei*.Flocculation mechanism of the actinomycete Streptomyces sp. hsn06 on chlorella vulgaris. Bioresource Technology 2017, 239: 137-143

12. Wang Hailei*, Li Ping, Wang Ying, LiuLei, Yao Jianming. Metagenomic insight into the bioaugmentation mechanism of Phanerochaete chrysosporium in anactivated sludge system treating cokingwastewater. Journal of Hazardous Materials 2017, 321: 820-829

13. Yi Li, Yanting Xu, Lei Liu, Xiaobing Jiang, KunZhang, Tianling Zheng, Hailei Wang *. First evidence of bioflocculant from Shinella albus with flocculationactivity on harvesting of Chlorella vulgaris biomass. Bioresource Technology 2016, 218: 807-815

14. Wang Hailei*, Li Ping, Qin Yu,Yang Hui. Removal ofphenol in phenolic resin wastewater by a novel biomaterial: the Phanerochaete chrysosporium pelletcontaining chlamydospore-like cells. Applied Microbiology Biotechnology 2016, 100(11): 5153-5164

15. Wang Hailei*, Li Ping, Jin Qianlong, Qin Ge. Specific aerobic granules can be developed in a completely mixed tank reactor by bioaugmentation using micro-mycelial pellets of Phanerochaete chrysosporium. Applied Microbiology Biotechnology 2014, 98: 2687-2697

專利成果：

1. 王海磊，王剛，劉宇峰，彭玉婉。一種適于切花菊連作障礙消除的土壤修復(fù)劑及其使用方法（ZL201410117044.2)，已授權(quán)

2. 王海磊，李平，劉國生。一種黃孢原毛平革菌厚垣孢子的培養(yǎng)方法(ZL201010553798.4) ，已授權(quán)

3. 曹媛媛，姚建銘，李俊，王冬梅，翟志軍，王海磊，王姍姍，嚴(yán)守保。一種利用餐廚廢棄物生產(chǎn)微生物油脂的方法( ZL200910184813) ，已授權(quán)

4. 王海磊，劉宇峰，楊玉華，李平。一種利用廢紙粉碎物提高靈芝漆酶產(chǎn)量的方法(ZL201410494078.3) ，已授權(quán)

5. 王海磊，王瑩，李平，李祎，劉磊。一種利用黃孢原毛平革菌固體發(fā)酵玉米秸稈生產(chǎn)厚垣孢子樣細(xì)胞的方法(201610117193.8)

6. 王海磊，秦雨，李祎，李平。一種用于處理高濃度苯酚廢水的微生物固化床反應(yīng)器（ZL201610306550.5)，已授權(quán)

7. 王海磊。一種天然紅色素的生產(chǎn)方法（CN201010553797.x）

8.王海磊，李平，張永梅。一株籃狀菌及利用該籃狀菌液體菌膜發(fā)酵生產(chǎn)甜菜苷的方法(ZL201710501743.0)，已授權(quán)

9.王海磊，閆越，宋潔，李平。利用黃孢原毛平革菌靜止固體發(fā)酵農(nóng)業(yè)廢棄物產(chǎn)生厚垣孢子并積累油脂的方法（201810402768.X）

10. 邵云，王海磊，張黛靜，胡永娟，馬建輝，姜麗娜。一種用于修復(fù)麥田重金屬鉻污染土壤的復(fù)合菌劑（CN 2014103911331.A）

11.王海磊，趙國威，魯欣欣。利用食烷菌發(fā)酵降解石蠟生產(chǎn)2-氧代己二酸的方法(ZL201811006963.7)，已授權(quán)

12. 李祎，王海磊，張志宇，劉磊，姜曉冰，張昆。一種高效收集微藻生物質(zhì)的絮凝物質(zhì)的提取方法及其應(yīng)用（CN201910321904.7）

13. 李祎，王海磊，張志宇，劉磊，姜曉冰，張昆。一種強效抑藻活性物質(zhì)的提取方法及其應(yīng)用（CN201910419644.7）

14. 王海磊，李卓婭，劉玉雪，王振宇，劉國生等。一種利用NsGfo氧化還原酶催化核苷合成阿糖核苷的方法（CN202011205047.3）.

15．王振宇，張震，劉玉雪，王海磊，劉國生。一種嘌呤/嘧啶核苷磷酸化酶串聯(lián)表達工程菌及應(yīng)用（CN202110425256.7）