孔祥會 博士 教授 博導
孔祥會，博士，二級教授，博士生導師。水產(chǎn)動物疾病控制河南省工程實驗室主任，河南省學術技術帶頭人，河南省科技創(chuàng)新杰出青年，河南省高校創(chuàng)新人才，水產(chǎn)一級學科帶頭人，水產(chǎn)博士學位授權點帶頭人，河南省創(chuàng)新型科技團隊帶頭人。獲河南省先進工作者，河南省優(yōu)秀黨員，河南省職業(yè)道德建設先進個人，河南師范大學首屆校園十大育人楷模等稱號?，F(xiàn)為中國水產(chǎn)學會理事，中國魚類學會理事，河南省水產(chǎn)學會秘書長。2004年獲廈門大學博士學位；2007年中科院水生所生物學博士后流動站完成博士后研究；2009-2010年在美國University of California, Los Angeles (UCLA)留學。
孔祥會教授長期以來從事水產(chǎn)動物免疫和疾病防控、免疫組學解析、疫苗研發(fā)和藥物創(chuàng)新等研究，并取得重要研究成果。主持國家自然科學基金3項,主持國家863項目子課題、河南省科技創(chuàng)新杰出青年計劃和河南省重點科技攻關項目等20余項；參與完成國家自然科學基金重點項目、國家973項目子課題、國家“藍色糧倉”重點專項等。在Aquaculture, Vaccine, Fish Shellfish Immun, J Fish Dis，中國科學和科學通報等重要學術刊物上發(fā)表學術論文160余篇，其中SCI源期刊收錄論文80余篇。出版學術專著3部，授權國家發(fā)明專利5項，獲河南省科技獎勵3項。
▊已取得的創(chuàng)新性成果
孔祥會教授創(chuàng)新性成果及科學發(fā)現(xiàn)主要有：（1）采用分子免疫學、免疫組學和生物信息學等技術方法，系統(tǒng)研究了病原感染后水產(chǎn)動物免疫響應模式、信號調(diào)控通路及其免疫調(diào)節(jié)機制。學術成果發(fā)表在Aquaculture、Fish & Shellfish Immunology等期刊發(fā)表。此外，還分別研究了抗菌肽、抗氧化酶、溶菌酶等不同的天然免疫相關基因及其對病原體的響應。（2）系統(tǒng)研究了水產(chǎn)動物重要病原的生物學和流行病學，弄清病原與機體互作、入侵致病過程及其致病機制，為疾病防控提供指導。取得的重要學術成果已在Aquaculture、Journal of fish disease等期刊發(fā)表上發(fā)表。（3）水產(chǎn)動物疫苗研發(fā)和疫苗導入技術。針對重要致病病原，研究和制備高效的滅活疫苗、弱毒疫苗和亞單位疫苗。取得的重要成果已在Vaccine、Fish & Shellfish Immunology等期刊發(fā)表；團隊自行研發(fā)的超聲波和高滲食鹽輔助浸浴法高效疫苗導入技術，對小規(guī)格魚種免疫有獨到優(yōu)勢，已推廣應用2000余畝，獲得較好的經(jīng)濟效益和生態(tài)效益。（4）新型綠色漁藥創(chuàng)制。利用代謝組學篩選水產(chǎn)動物小分子代謝物，作為漁藥增效劑，以大幅減量漁藥使用。研發(fā)適用于水產(chǎn)動物的中草藥制劑和免疫增加劑，以增強機體免疫，預防疾病的發(fā)生。
▊代表性科研項目
（1）主持國家自然科學基金聯(lián)合基金項目（U2004154），項目名稱：嗜水氣單胞菌感染后黃河鯉IL-1β生成和分泌調(diào)控的分子機制研究，在研，項目執(zhí)行期：2021-2023。
（2）主持國家自然科學基金聯(lián)合基金項目(U1604104)，項目名稱：草魚pIgR受體結合和轉(zhuǎn)運IgM的分子機制研究，結項。
（3）主持國家自然科學基金項目(30770299)，項目名稱: 尺寸控制基因調(diào)控序列在鯉科魚類中的變異及系統(tǒng)演化，結項。
（4）主持河南省科技創(chuàng)新杰出青年計劃(124100510017)，項目名稱：魚類組蛋白H2B衍生抗菌肽基因變異對抗菌影響及高活性抗菌肽篩選，結項。
（5）主持河南省高?？萍紕?chuàng)新團隊支持計劃（15IRTSTHN018），團隊名稱：水產(chǎn)動物醫(yī)學，結項。
（6）主持河南省高?？萍紕?chuàng)新人才支持計劃(2011HASTIT012)，項目名稱：魚類低氧誘導因子HIF-1α分子進化和基因改造及作用研究，結項。
▊代表性學術論文
孔祥會近5年以第一作者或通訊作者發(fā)表的代表性論文：
【1】Yuan Gaoliang#, Zhu Lei#, Jiang Xinyu, Zhang Jie, Pei Chao, Zhao Xianliang, Li Li, Kong Xianghui*. Diagnosis of co-infection with white spot syndrome virus and Aeromonas veronii in red swamp crayfish Procambarus clarkia. Aquaculture, 2021,532: 736010.
【2】Zhu Lei#, Yuan Gaoliang#, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Molecular characterization of Rab5 and Rab6, and their involvement in innate immunity in red swamp crayfish Procambarus clarkia. Aquaculture, 2021,533: 736085.
【3】Zhu Lei, Gao Yuanyuan, Yuan Gaoliang, Jiang Xinyu, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Identification and immune functional analysis of a novel C1q domain-containing protein in Yellow River Carp (Cyprinus carpio L.). Aquaculture, 2021,534: 736313.
【4】Wang Li, Zhang Jie, Zhao Xianliang, Pei Chao, Li Li, Kong Xianghui*. Molecular characterization and biological function of a tandem-repeat galectin-9 in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2020,103: 366-376.
【5】Wu Limin, Li Yongjing, Xu Yufeng, Wang Lei, Ma Xiao, Dong Chuanju, Zhao Xianliang, TianXue, Li Xuejun*, Kong Xianghui*. The roles of two myostatins and immune effects after inhibition in Qi river crucian carp (Carassius auratus). Fish & Shellfish Immunology, 2020, 98: 710-719.
【6】Zhao Xian-liang, Wu Gan, Chen He, Li Li, Kong Xiang-hui*. Analysis of virulence and immunogenic factors in Aeromonas hydrophila: Towards the development of live vaccines. Journal of Fish Disease, 2020,43:747-755.
【7】Zhang Jie, Zhu Yachen, Chen Zhuo, Li Chunjing, Zhao Xianliang, Kong Xianghui*. Molecular cloning and expression analysis of MyD88 and TRAF6 in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2019, 87: 829-838.
【8】Gao Yan, Pei Chao, Sun Xiaoying, Zhang Chao, Li Li, Kong Xianghui*. Novel subunit vaccine based on grass carp reovirus VP35 protein provides protective immunity against grass carp hemorrhagic disease. Fish and Shellfish Immunology, 2018, 75:91-98.
【9】Zhao Xianliang, Chen He, Jin Zhaohui, Li Li, Zhang Jie, Kong Xianghui*. GC-MS-based metabolomics analysis reveals L‐aspartate enhances the antibiotic sensitivity of neomycin sulfate-resistant Aeromonas hydrophila. Journal of fish diseases, 2018, 41(12): 1831-1841.
【10】Gao Yan #, Pei Chao #, Sun Xiaoying, Zhang Chao, Li Li, Kong Xianghui*. Plasmid pcDNA3.1-s11 constructed based on the S11 segment of grass carp reovirus as DNA vaccine provides immune protection. Vaccine, 2018, 36:3613-3621.
【11】Kong Xianghui*, Wang Li, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li. Comparison of polymeric immunoglobulin receptor between fish and mammals. Veterinary Immunology and Immunopathology, 2018,202: 63-69.
【12】Zhao Xianliang, Chen He, Zhong Keke, Li Li, Kong Xianghui*. Myo-inositol as an adjuvant to florfenicol against Aeromonas hydrophila infection in common carp Cyprinus carpio. FEMS Microbiology Letters, 2018, 365(20): fny212.
【13】Zhang Jie, Wang Li, Zhao Yanjing, Kong Xianghui*, Wu Fan, Zhao Xianliang. Molecular characterization and expression analysis of toll-like receptors 5 and 22 from natural triploid Carassius auratus.Fish and Shellfish Immunology,2017,64:1-13.
【14】Kong Xianghui*, Wu Xiangmin, Pei Chao, Zhang Jie, Zhao Xianliang, Li Li, Nie Guoxing, Li Xuejun. H2A and Ca-L-hipposin gene: Characteristic analysis and expression responses to Aeromonas hydrophila infection in Carassius aurutus. Fish and Shellfish Immunology, 2017,63: 344-352.
【15】Di Guilan, Li Hui, Zhang Chao, Zhao Yanjing, Zhou Chuanjiang, Naeem Sajid, Li Li, Kong Xianghui*. Label-free proteomic analysis of intestinal mucosa proteins in common carp (Cyprinus carpio) infected with Aeromonas hydrophila. Fish and Shellfish Immunology, 2017, 66: 11-25.
【16】Wang Li, Zhang Jie, Kong Xianghui*, Zhao Xianliang, Pei Chao, Li Li. A C-type lectin, Nattectin-like protein (CaNTC) in Qihe crucian carp Carassius auratus: Binding ability with LPS, PGN and various bacteria, and agglutinating activity against bacteria. Fish and Shellfish Immunology, 2017, 67: 382-392.
【17】Kong Xianghui*, Qiao Dan, Zhao Xianliang, Wang Li, Zhang Jie, Liu Dandan , Zhang Hongxu. The molecular characterizations of Cu/ZnSOD and MnSOD and its responses of mRNA expression and enzyme activity to Aeromonas hydrophila or lipopolysaccharide challenge in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2017, 67: 429-440.
【18】Wang Li, Zhang Jie, Kong Xianghui*, Pei Chao, Zhao Xianliang, Li Li. Molecular characterization of polymeric immunoglobulin receptor and expression response to Aeromonas hydrophila challenge in Carassius auratus. Fish and Shellfish Immunology, 2017, 70: 372-380.
【19】Zhao Yanjing, Jiang Xinyu, Kong Xianghui*, Di Guilan, Nie Guoxing，Li Xuejun. Effects of hypoxia on lysozyme activity and antioxidant defences in the kidney and spleen of Carassius auratus. Aquaculture Research, 2017, 48: 223-235.
【20】Wang Meijuan, Zhao Xianliang, Kong Xianghui*, Wang Li, Jiao Dan, Zhang Hongxu. Molecular characterization and expressing analysis of the c-type and g-type lysozymes in Qihe crucian carp Carassius auratus. Fish and Shellfish Immunology, 2016, 52: 210-220.
【21】Jiang Xinyu, Zhang Chao, Zhao Yanjing, Kong Xianghui*,Pei Chao, Li Li, Nie Guoxing, Li Xuejun. Immune effects of the vaccine for live attenuated Aeromonas hydrophila screened using rifampicin on common carp (Cyprinus carpio L.). Vaccine, 2016, 34(27):3087-3092.
【22】Zhang Jie, Chen Zhuo, Zhou Chuanjiang, Kong Xianghui*. Molecular phylogeny of the subfamily Schizothoracinae (Teleostei: Cypriniformes: Cyprinidae) inferred from complete mitochondrial genomes. Biochemical Systematics and Ecology, 2016,64: 6-13.
【23】Jiang Hongxia, Kong Xianghui*, Wang Shuping, Guo Huiyun. Effect of copper on growth, digestive and antioxidant enzyme activities of juvenile Qihe crucian carp during exposure and recovery. Bulletin of Environmental Contamination and Toxicology, 2016, 96:333-340.
【24】趙燕靜，狄桂蘭，孔祥會*，張杰，李莉，聶國興，李學軍. 低氧環(huán)境下poly I:C刺激對淇河鯽肝胰臟抗氧化防護的影響，水產(chǎn)學報，2016, 40: 1830-1841.
▊科研團隊理念
做一流學問，樹一流人品，育一流人才
▊研究生招生和博士后入站
碩士生招生：水產(chǎn)一級碩士點
學術型碩士：水產(chǎn)動物醫(yī)學方向；
專業(yè)型碩士：水產(chǎn)動物疾病防控方向。
博士生招生：水產(chǎn)一級博士點
招生方向：水產(chǎn)動物醫(yī)學（水產(chǎn)動物免疫和疾病防控）；
博士后入站：生物學博士后流動站常年招收博士后
▊聯(lián)系方式
河南省新鄉(xiāng)市建設路46號，河南師范大學水產(chǎn)學院，郵編：453007
電子郵件：xhkong@htu.cn；xhkong@htu.edu.cn
歡迎有志之士加盟我們的科研團隊，走進科學殿堂，探索科學奧秘。
