仉華

河北省石家莊市人；博士，教授,博士生導(dǎo)師,2017年獲得國(guó)家優(yōu)秀青年科學(xué)基金資助，河南省優(yōu)秀專家，河南省模范教師，河南省學(xué)術(shù)技術(shù)帶頭人，河南省高校科技創(chuàng)新團(tuán)隊(duì)帶頭人，河南省教育廳學(xué)術(shù)技術(shù)帶頭人，河南省高?？萍紕?chuàng)新人才，新鄉(xiāng)市創(chuàng)新人才。中國(guó)感光學(xué)會(huì)光學(xué)傳感與診療專業(yè)委員會(huì)委員、河南省化學(xué)會(huì)理事、河南省青年科技工作者協(xié)會(huì)理事兼高校界別工作委員會(huì)秘書(shū)長(zhǎng)。

E-mail:zhanghua1106@163.com

講課程：

分析化學(xué)、儀器分析、染料功能調(diào)控、熒光分析法

研究領(lǐng)域：

染料功能調(diào)控與生物成像；

識(shí)別特殊蛋白質(zhì)/酶、核酸的新型雙光子熒光染料的設(shè)計(jì)及其生物應(yīng)用；

用于疾病診斷的雙光子熒光技術(shù)的研究和開(kāi)發(fā)；

近年來(lái)主持的主要科研項(xiàng)目：

1、生化分析與生物成像，國(guó)家優(yōu)秀青年科學(xué)基金項(xiàng)目，2018.1-2020.12，項(xiàng)目編號(hào)：21722501 

2、反應(yīng)型Sequential-ICT熒光探針及雙功能酶活性的生化分析與成像，2020.1-2021.12，204200510006

3、生物酶靶向功能有機(jī)小分子雙光子熒光染料的構(gòu)建及其在疾病診斷成像中的應(yīng)用研究，國(guó)家自然科學(xué)基金項(xiàng)目，2015.1-2017.12，項(xiàng)目編號(hào)：21402043

4、有機(jī)小分子雙光子熒光染料的功能調(diào)控及其在疾病診斷中的應(yīng)用，河南省基礎(chǔ)與前沿技術(shù)研究計(jì)劃資助項(xiàng)目，2014.2-2015.8，項(xiàng)目編號(hào)：142300410421

5、耐候型懸乳聚合染料/顏料微球彩色墨粉的構(gòu)建及其在圖像輸出中的應(yīng)用，河南省重點(diǎn)科技攻關(guān)計(jì)劃項(xiàng)目,2015.1-2017.12，項(xiàng)目編號(hào)：152102210082

6、用于大幅面打印的耐曬型酞菁類青色染料合成工藝的研究及其應(yīng)用，河南省高等學(xué)校重點(diǎn)科研項(xiàng)目,2015.1-2016.12，項(xiàng)目編號(hào)：15A150017

7、端基官能化熒光染料的構(gòu)建及其在腫瘤細(xì)胞亞結(jié)構(gòu)成像中的應(yīng)用研究，新鄉(xiāng)市科技創(chuàng)新人才計(jì)劃，2015.8-2017.8，項(xiàng)目編號(hào)：RC15002

8、光致開(kāi)關(guān)末端功能化的有機(jī)小分子熒光染料的構(gòu)建及其在腫瘤細(xì)胞多種亞結(jié)構(gòu)同時(shí)超分辨成像中的應(yīng)用研究,河南師范大學(xué)優(yōu)秀青年科學(xué)基金項(xiàng)目，2015.1-2017.12，項(xiàng)目編號(hào)：14YQ002

9、靶向生物標(biāo)記物的雙光子熒光染料的構(gòu)建，精細(xì)化工國(guó)家重點(diǎn)實(shí)驗(yàn)室開(kāi)放課題基金資助項(xiàng)目，2015.12-2018.3，項(xiàng)目編號(hào)：KF1510

10、端基官能化熒光染料的構(gòu)建及其在生物成像分析中的應(yīng)用研究，新鄉(xiāng)市錦源化工有限公司橫向項(xiàng)目，2016.9-2021.8，項(xiàng)目經(jīng)費(fèi)：50萬(wàn)

11、DNA熒光探針的構(gòu)建及其對(duì)DNA損傷精準(zhǔn)測(cè)量與成像的性能研究，河南省高?？萍紕?chuàng)新人才支持計(jì)劃，2018.1-2019.12，項(xiàng)目編號(hào)：18HASTIT001  

代表性成果：

<文章>

29.Jun W. Liu, Yong G. Yang, Kui Wang, Ge Wang, Cong C. Shen, Yue H. Chen, Yu F. Liu, Tony D. James, Kai Jiang, and Hua Zhang*, Activation and monitoring of mtDNA damage in cancer cells via the “Proton-Triggered” decomposition of an ultrathin nanosheet, ACS Applied Materials & Interfaces,  2021, 13, 3669-3678.(IF=8.758)

28.Yuehua Chen, Yuzhu Wang, Yonggang Yang, Yuhuan Li, Yafu Wang, Ge Wang, Tony D. James*, Xiaopeng Xuan, Hua Zhang*  and  Yufang Liu, A molecular-logic gate for COX-2 and NAT based on conformational and structural changes: visualizing the progression of liver disease, Chemical Science, 2020, 11, 6209–6216.(IF=9.346)

27.Beidou Feng, Kui Wang, Yonggang Yang, Ge Wang, Hua Zhang*, Yufang Liu and Kai Jiang. Ultrasensitive recognition of AP sites in DNA at the single-cell level: one molecular rotor sequentially self-regulated to form multiple different stable conformations, Chemical Science, 2019, 10, 10373–10380.(IF=9.346)

26.Feng Beidou, Wang Kui, Junwei Liu, Guojiang Mao, Jingqiang Cui, Xiaopeng Xuan, Kai Jiang, and Hua Zhang*. Ultrasensitive apurinic/apyrimidinic site-specific ratio fluorescent rotor for real-time highly selective evaluation of mtDNA oxidative damage in living cells, Analytical Chemistry.2019,91,13962?13969.(IF=6.785)

25.Tao Jiang, Xin Wang, Ge Wang, Yafu Wang, Kui Wang, Xiaopeng Xuan, Changpo Chen*, Kai Jiang, Hua Zhang*. Light-activated "cycle-reversible intramolecular charge transfer" fluorescent probe: monitoring of pHi trace change induced by UV light in programmed cell death, Chem. Commun.2019, 55,5279-5282.(IF=5.996)

24.Yafu Wang,Ge Wang, Kui Wang, Zaoxia Wang, Yuming Guo, Hua Zhang*. A lysosomes-targeted ratio fluorescent probe for real-time monitoring of micropolarity in cancer cells, Sensors and Actuators B: Chemical. 2018,261,210-217.(IF=7.1)

23.JianPing Li, Shuang Xia, Hua Zhang*, GuiRong Qu, HaiMing Guo*, Three-input “AND-Type” fluorescent logic gate as ratio probe for specific imaging of hypochlorite in rough endoplasmic reticulum, Sensors and Actuators B: Chemical. 2018,255,622-629.(IF=7.1)

22.Caixia Wang, Ge Wang, Xiang Li, Kui Wang, Jing Fan, Kai Jiang, Yuming Guo,Hua Zhang*. Highly sensitive fluorescence molecular switch for the ratio monitoring of trace change of mitochondrial membrane potential.Analytical Chemistry.2017,89,11514–11519.(IF=6.785)

21.Hua Zhang*, Yafu Wang, Xiaopeng Xuan, Ge Wang, Haiming Guo, Jiangli Fan*. A dynamic invertible intramolecular charge-transfer fluorescence probe: real-time monitoring of mitochondrial ATPase activity.Chem. Commun. 2017,53, 5535-5538.(IF=5.996)

20.Hua Zhang*, Caixia Wang, Kui Wang, Xiaopeng Xuan, Qingzhang Lv, Kai Jiang*. Ultrasensitive fluorescent ratio imaging probe for the detection of glutathione ultratrace change in mitochondria of cancer cells. Biosensors and Bioelectronics. 2016,85,96–102.(IF=10.257)

19.Jianping Li, Yanyan Zhang,Hua Zhang*, Xiaopeng Xuan, Mingsheng Xie, Shuang Xia, Guirong Qu, Haiming Guo*. Nucleoside-based ultrasensitive fluorescent probe for the dual-mode imaging of microviscosity in living cells.Analytical Chemistry. 2016, 88,5554-5560.(IF=6.785)

18.Hua Zhang*,Kui Wang, Xiaopeng Xuan, Qingzhang Lv, Yamin Nie, Haiming Guo*. Cancer cell-targeted two-photon fluorescence probe for the real-time ratiometric imaging of DNA damage.Chem. Commun. 2016,52, 6308-6311.(IF=5.996)

17.Hua Zhang*, Caixia Wang, Ge Wang, Kui Wang, Kai Jiang*. Thrombin-mediated ratiometric two-photon fluorescent probe for selective imaging of endogenous ultratrace glutathione in platelet. Biosensors and Bioelectronics. 2016, 78, 344-350.(IF=10.257)

16.Hua Zhang* , Caixia Wang , Tao Jiang , Haiming Guo* , Ge Wang , Xinhua Cai , Lin Yang , Yi Zhang , Haichuan Yu , Hui Wang , and Kai Jiang . Microtubule-targetable fluorescent probe: site-specific detection and super-resolution imaging of ultratrace tubulin in microtubules of living cancer cells. Analytical Chemistry.2015, 87, 5216-5222. (IF=6.785)

15.Hua Zhang*,Jiangli Fan,Kui Wang,Jing Li,Caixia Wang,Yamin Nie,Tao Jiang,Huiying Mu,Xiaojun Peng,and Kai Jiang. Highly sensitive naphthalene-based two-photon fluorescent probefor in situ real-time bioimaging of ultratrace cyclooxygenase?2 in living biosystems. Analytical Chemistry.2014, 86, 9131-9138. (IF=6.785)

14.Hua Zhang, Jiangli Fan, Jingyun Wang, Shuangzhe Zhang, Bairui Dou, and Xiaojun Peng*. An Off–On COX-2-specific fluorescent dye: targeting the Golgi apparatus of cancer cells. J. Am. Chem. Soc.,2013, 135, 11663-11669. (IF=14.612)

13.Hua Zhang, Jiangli Fan, Jingyun Wang, Bairui Dou, Fan Zhou, Jianfang Cao, Junle Qu, Zhi Cao, Weijie Zhao, and and Xiaojun Peng*. Fluorescence discrimination of cancer from inflammation by molecular response to COX- 2 enzymes. J. Am. Chem. Soc.,2013, 135, 17469-17475.(IF=14.612)

12.Hua Zhang, Jiangli Fan, Huijuan Dong, Shuangzhe Zhang, Wenyou Xu, Jingyun Wang, Pan Gao, and Xiaojun Peng*. Fluorene-derived two-photon fluorescent dyes for specific and simultaneous bioimaging of endoplasmic reticulum and lysosomes: group-effect and localization.J. Mater. Chem. B.,2013, 1, 5450-5455.(IF=5.344)

11.Zhiyong Li, Shiguo Sun, Zhigang Yang, Si Zhang,Hua Zhang, Mingming Hu, Jianfang Cao, Jingyun Wang, Fengyu Liu, Fengling Song, Jiangli Fan and Xiaojun Peng*. The use of a near-infrared RNA fluorescent dye with a large Stokes shift for imaging living cells assisted by the macrocyclic molecule CB7.Biomaterials.,2013, 34, 6473-6481.(IF=8.387)

10.Jiangli Fan, Huijuan Dong, Mingming Hu, Jingyun Wang,Hua Zhang, Hao Zhu, Wen Sun and Xiaojun Peng*. Fluorescence imaging lysosomal changes during cell division and apoptosis observed using Nile Blue based near-infrared emission.Chem. Commun.,2014, 50, 882-884. (IF=6.567)

9.Wen Sun, Jiangli Fan, Chong Hu, Jianfang Cao,Hua Zhang, Xiaoqing Xiong, Jingyun Wang, Shuang Cui, Shiguo Sun and Xiaojun Peng*. A two-photon fluorescent dye with near-infrared emission for hydrogen sulfide imaging in biosystems.Chem. Commun.,2013, 49, 3890-3892. (IF=6.567)

8.Liu Fei , Wu Tong, Cao Jianfang,Zhang Hua, Hu Mingming, Sun Shiguo, Song Fengling, Fan Jiangli, Wang Jingyun, Peng Xiaojun*. A novel fluorescent sensor for detection of highly reactive oxygen species, and for imaging such endogenous hROS in the mitochondria of living cells. Analyst.,2013,138,775-778. (IF=4.033)

7. Hu Mingming,Fan Jiangli,Cao Jianfang,Zhang Hua,Sun Shiguo,Peng Xiaojun*. Enhanced fluorescent chemosensor for Ag⁺ in absolute aqueous solution and living cells: An experimental and theoretical study.Analyst.,2012, 137, 2107-2011. (IF=4.033)

6.Zhang Hua, Li Jing, Du Xinzhen, Li Quanmin*. A simple and sensitive assay for ascorbate using potassium ferricyanide as spectroscopic probe reagent. Anal. Biochem.,2009, 388(1):40-46. (IF=2.305)

5.Zhang Hua, Zhang Yan, Wei Xianjun, Du Xinzhen, Li Quanmin*. A novel spectrophotometric methodfor the determination of isoniazid using Cu (II) as spectroscopic probeIon. Chinese. J.Chem.,2009, 27(3):518-522.(IF=0.971)

4.Zhang Hua, Wu Lingli, Li Quanmin*, Du Xinzhen. Determinationofisoniazid among pharmaceutical and the patients’ saliva samples by using potassium ferricyanide as spectroscopicprobereagent. Anal. Chim. Acta.,2008, 628(1):67-72. (IF=4.517)

3.ZhangHua, Wu Lingli, Li Quanmin*, Du Xinzhen. A novel method for the spectrophotometric determination of cefradine by using sodium nitroprusside as chromogenicreagent. Chin.Chem. Lett.,2008, 19(12):1470-1474. (IF=1.21)

2.仉華, 吳伶俐, 李全民, 杜新貞.硝酸鉀-硫氰酸銨-水體系萃取浮選銅間接測(cè)定甲巰咪唑. 分析試驗(yàn)室,2008,27(12):103-106.

1.李晶,仉華, 李全民, 杜新貞.硝酸鉀-硫氰酸銨-水體系萃取浮選硫氰酸亞銅間接測(cè)定頭孢拉定. 應(yīng)用化學(xué),2008,25(9):1095-1100.

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