| 教育與研究經歷： 1997,09- 2001,07河南師范大學化學與環(huán)境科學學院化學教育專業(yè)理學學士 2001,09 - 2004,07河南師范大學化學與環(huán)境科學學院有機化學專業(yè)理學碩士 2004,08 -2007,07 北京大學藥學院，天然產物與仿生藥物國家重點實驗室，化學生物學專業(yè)博士 2009,12-2010,06美國內華達大學醫(yī)學院，生理學系，NIH訪問學者 2011, 12- 2012.12美國Scripps研究所，化學生物學專業(yè)博士后 2007,07-至今河南師范大學化學與化工學院副教授，教授
主講課程： 《化學生物學概論》，《核酸藥物化學》，《波譜分析與實驗》 研究領域與興趣： 核酸化學生物學，生物有機化學，高通量化學生物學方法 近年來主持的主要科研項目: 國家自然科學基金項目(21778015): 蛋白質ADP-核糖化穩(wěn)定結構模擬物的設計合成及化學遺傳學研究(2018-2021) 國家自然科學基金項目(21172058): 基于靶導向合成(TGS)策略新型NAD+類似物的設計合成及活性研究(2012-2015) 河南省科技創(chuàng)新杰出青年支持計劃（164100510020：基于人造基因密碼的核酸定點標記技術及應用（2016-2018） 河南省高校創(chuàng)新人才支持計劃(2012HASTIT10): 新型核苷酸類細胞信號分子的設計合成及活性研究(2012-2014) 國家自然科學基金項目(20802017): 基于click化學的新型簡單結構cADPR 類似物的設計合成及活性研究 (2009-2011)
代表性論文：
Feldman, Aaron W.;? Dien, Vivian T.;? Karadeema, Rebekah J.; Fischer, Emil C.; You, Yanbo; Chen, Jason S; Li, Lingjun.*; Romesberg, Floyd. E.* Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism. J. Am. Chem. Soc. 2019, 141 (27), 10644-10653. (IF = 14.357) Li, Lingjun; Degardin, Melissa; Lavergne, Thomas; Malyshev, Denis A.; Dhami, Kirandeep; Ordoukhanian, Phillip; Romesberg, Floyd E.* Natural-like Replication of an Unnatural Base Pair for the Expansion of the Genetic Alphabet and Biotechnology Applications. J. Am. Chem. Soc. 2014, 136 (3), 826-829. (IF = 14.357) Zhang, Yorke; Lamb, Brian M; Feldman, Aaron W; Zhou, Anne Xiaozhou; Lavergne, Thomas; Li, Lingjun; Romesberg, Floyd E*. A semisynthetic organism engineered for the stable expansion of the genetic alphabet. Proc. Natl. Acad. Sci. U S A 2017, 114 (6), 1317-1322. (IF = 9.674) Zhu, Anlian; Li, Lingjun;* Zhang, Chi; Shen Yutan; Tang, Mingjie, Bai, Lili; Du, Chunyan; Zhang, Suojiang; Wang, Jianji* An Integrated High-throughput Strategy Enables the Discovery of Multifunctional Ionic Liquids for Sustainable Chemical Processes. Green Chem. 2019, 21(2), 307-313. (IF = 9.405) Zhu, Anlian;* Xing, Xiaofang; Wang, Shilei; Yuan, Donghe; Zhu, Gongmin; Geng, Mingwei; Guo, Yuanyang; Zhang, Guisheng; Li, Lingjun* Multi-component Syntheses of Diverse 5-Fluoroalkyl-1,2,3-triazoles Facilitated by Air Oxidation and Copper Catalysis. Green Chem. 2019, 21 (12), 3407- 3412 (IF = 9.405) Li, Lingjun*; Ding, Shengqiang; Yang, Yanping; Zhu, Anlian; Fan, Xincui; Cui, Mengchao*; Chen, Changpo; Zhang, Guisheng*. Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles: Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling. Chemistry-A European Journal 2017, 23 (5), 1166-1172. (IF = 5.160) Li, Lingjun;* Huang, Shenlong; Shang, Tongpeng, Zhang, Bo; Guo, Yuanyang; Zhu, Gongming; Zhou, Demin;* Zhang, Guisheng;* Zhu, Anlian; Zhang Lihe. Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands. J. Org. Chem. 2018, 83(21), 13166?13177. (IF = 4.85) Lavergne, T.; Lamichhane, R.; Malyshev, D. A.; Li, Zhengtao Li; Li, Lingjun; Sperling, Edit ; Williamson, James R.; Millar, David P.; Romesberg. Floyd E. FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs. ACS Chem. Biol., 2016. 11(5), 1347?1353. (IF = 5.331)
|
