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          張新迎個(gè)人簡(jiǎn)介
          
			        	
          時(shí)間：2012-11-26瀏覽：11830設(shè)置
          
			        	
			        	
          
			            	
           
          張新迎
          博士，教授，博士生導(dǎo)師。
          電話：0373-3329261；E-mail：xinyingzhang@htu.cn
           
           
           
          教育與工作經(jīng)歷：
          1987.09-1991.06   河南師范大學(xué)，化學(xué)專(zhuān)業(yè)，理學(xué)學(xué)士
          1991.09-1994.06   河南師范大學(xué)，有機(jī)化學(xué)專(zhuān)業(yè)，理學(xué)碩士
          1994.07-2004.07   河南師范大學(xué)，助教、講師、副教授
          2004.08-2006.12   美國(guó)北亞利桑那大學(xué)及馬里蘭大學(xué)，訪問(wèn)學(xué)者
          2007.01-2007.08   河南師范大學(xué)，副教授
          2007.09-2010.06   河南師范大學(xué)，環(huán)境科學(xué)專(zhuān)業(yè)，工學(xué)博士
          2010.07 至今   河南師范大學(xué)，教授

          主講課程：
          物理有機(jī)化學(xué)；高等有機(jī)化學(xué)；有機(jī)化學(xué)實(shí)驗(yàn)

          研究領(lǐng)域與興趣：
          1. 綠色合成新方法研究
          2. 新型核苷衍生物的綠色合成及生物活性研究

          近年來(lái)主持的主要科研項(xiàng)目:
          1. 河南省高?？萍紕?chuàng)新團(tuán)隊(duì)支持計(jì)劃（20IRTSTHN005）：有機(jī)功能分子的綠色合成及性能研究，2020.01-2021.12。
          2. 河南省高校科技創(chuàng)新人才支持計(jì)劃（15HASTIT005）：噻吩、呋喃及吡喃并嘧啶雙環(huán)核苷的綠色合成及性能研究，2015.01-2017.12。
          3. 國(guó)家自然科學(xué)基金項(xiàng)目（21172057）：新型六元雜環(huán)并嘧啶雙環(huán)核苷的設(shè)計(jì)、合成及生物活性研究，2012.01-2015.12。
          4. 河南省基礎(chǔ)與前沿技術(shù)研究項(xiàng)目（092300410237）：嘧啶核苷—?dú)浠s化體的合成及生物活性研究。
          5. 河南省國(guó)際科技合作項(xiàng)目（094300510054）：5-取代嘧啶碳環(huán)核苷的合成及抗病毒活性研究。
          6. 河南省教育廳自然科學(xué)基金項(xiàng)目（2009A150017）：新型核苷類(lèi)似物的綠色合成及生物活性研究。

          代表性論文：
          35. Yuanshuang Xu, Mengyang Shen, Xinying Zhang*, and Xuesen Fan*. Selective Synthesis of Pyrazolo[1,2-a]pyrazolones and 2-Acylindoles via Rh(III)-Catalyzed   Tunable Redox-Neutral Coupling of 1-Phenylpyrazolidinones with Alkynyl Cyclobutanols. Org. Lett., 2020, 22, 4697-4702. 
          34. Linghua Zhang, Yuanshuang Xu, Xiaopeng Zhang, Xinying Zhang*, and Xuesen Fan*. Synthesis of Pyrazolone Fused Benzodiazepines via Rh(III)-Catalyzed [4 + 3] Annulation of 1-Phenylpyrazolidinones with Propargyl Alcohols. Org. Chem. Front., 2020, 7, 2284-2290.
          33. Yuanshuang Xu, Linghua Zhang, Mengyang Liu, Xiaopeng Zhang, Xinying Zhang*, and Xuesen Fan*. Synthesis of Benzoazepine Derivatives via Rh(III)-catalyzed Inert C(sp2)-H Functionalization and [4 + 3] Annulations. Org. Biomol. Chem., 2019, 17, 8706-8710. 
          32. Cai Gao, Bin Li, Xueyang Geng, Qianting Zhou, Xinying Zhang*, and Xuesen Fan*. Two Birds with One Stone: One-pot Simultaneous Synthesis of 2,2,2-Trifluoroethyl phenanthridines and Benzochromenones Featuring the Utilization of the Byproduct of Togni’s Reagent. Green Chem., 2019, 21, 5113-5117. 
          31. Xi Chen, Muhua Wang, Xinying Zhang*, and Xuesen Fan*. Rh(III)-Catalyzed Cascade Reactions of Sulfoxonium Ylides with α-Diazocarbonyl Compounds: An Access to Highly Functionalized Naphthalenones. Org. Lett., 2019, 21, 2541-2545.
          30. Qianqian Wang, Xinying Zhang*, and Xuesen Fan*. Synthesis of 2-Aminobenzophenones through Acylation of Anilines with α-Oxocarboxylic Acids Assisted by tert-Butyl Nitrite. Org. Biomol. Chem., 2018, 16, 7737-7747.
          29. Xia Song, Cai Gao, Xinying Zhang*, and Xuesen Fan*. Synthesis of Diversely Functionalized 2H-Chromenes through Pd-Catalyzed Cascade Reactions of 1,1-Dibromoolefin Derivatives with Arylboronic Acids. J. Org. Chem., 2018, 83, 15256-15267.
          28. Xia Song, Cai Gao, Bin Li, Xinying Zhang*, and Xuesen Fan*. Regioselective Synthesis of 2-Alkenylindoles and 2-Alkenylindole-3-carboxylates through the Cascade Reactions of N-Nitrosoanilines with Propargyl Alcohols. J. Org. Chem., 2018, 83, 8509-8521. 
          27. Yuanshuang Xu, Bin Li, Xinying Zhang*, and Xuesen Fan*. One-Pot Synthesis of Fused N,O-Heterocycles through Rh(III)-Catalyzed Cascade Reactions of Aromatic/Vinylic N-Alkoxyamides with 4-Hydroxy-2-alkynoates. Adv. Synth. Catal., 2018, 360, 2613-2620. 
          26. Qianqian Wang, Zhangxin Wang, Xinying Zhang*, and Xuesen Fan*. Microwave-Promoted Metal-Free α-Alkylation of Ketones with Cycloalkanes through Cross-Coupling of C(sp3)-H Bonds. Asian J. Org. Chem., 2017, 6, 1445-1450. 
          25. Yuanshuang Xu, Bin Li, Xinying Zhang*, and Xuesen Fan*. Metal-Free Synthesis of 2-Aminobenzothiazoles via Iodine-Catalyzed and Oxygen-Promoted Cascade Reactions of Isothiocyanatobenzenes with Amines. J. Org. Chem., 2017, 82, 9637-9646.
          24. Qianqian Wang, Zhangxin Wang, Yuanshuang Xu, Xinying Zhang,* and Xuesen Fan*. Bu4NI-Catalyzed and tBuOOH-Oxidized Esterification of Aldehydes with Alkyl Halides in Water. Asian J. Org. Chem., 2016, 5, 1304-1308. 
          23. Shitao Duan, Yuanshuang Xu, Xinying Zhang*, and Xuesen Fan*. Synthesis of 2,2’-Biphenols through Direct C(sp2)–H Hydroxylation of [1,1’-biphenyl]-2-ols. Chem. Commun., 2016, 52, 10529-10532.
          22. Xinying Zhang*, Zhangxin Wang, Xuesen Fan*, and Jianji Wang. Synthesis of Ketones through Microwave Irradiation Promoted Metal-free Alkylation of Aldehydes by Activation of C(sp3)?H Bond. J. Org. Chem., 2015, 80, 10660-10667.
          21. Xinying Zhang*, Xiaojie Guo, and Xuesen Fan*. Synthesis of 2-Aminoquinoline-3-carboamides and Pyrimido[4,5-b]quinolin-4-ones through Copper-Catalyzed One-pot Multicomponent Reactions. Chem. Asian J., 2015, 10, 106-111.
          20. 宰文靜，蔣盼盼，張新迎*，Philippe M. Loiseau，郭勝海，范學(xué)森*. 嘧啶核苷-查爾酮雜化體的合成及其抗利什曼原蟲(chóng)活性研究. 有機(jī)化學(xué), 2015, 35, 1335-1341.
          19. Yan He, Xinying Zhang*, and Xuesen Fan*. One-pot Cascade Reactions of 1-Arylpenta-3,4-dien-2-ones Leading to 2-Arylphenols and Dibenzopyroanones. Chem. Commun., 2014, 50, 14968-14970.
          18. Xinying Zhang,* Yunping Song, Lin Gao, Xiaojie Guo, and Xuesen Fan*. Highly Facile and Regio-selective Synthesis of Pyrazolo[1,5-a]pyrimidines via Reactions of 1,2-Allenic Ketones with Aminopyrazoles. Org. Biomol. Chem., 2014, 12, 2099-2107.
          17. Xinying Zhang*, Xiaojie Guo, Liangliang Fang, Yunping Song, and Xuesen Fan*. Copper-catalyzed N- and O-arylation of Amides: Alternative Approaches to 3,4- Dihydroquinolin-2-ones, Quinolin-2-ones, and 12H-Chromeno[2,3-b]quinolin-12-ones. Eur. J. Org. Chem., 2013, 8087-8093.
          16. Yan He, Xinying Zhang*, Liangyan Cui, Jianji wang, and Xuesen Fan*. Catalyst-free Synthesis of Diversely Substituted 6H-Benzo[c]chromenes and 6H-Benzo[c]-chromen-6-ones in Aqueous Media under MWI. Green Chem., 2012, 14, 3429-3435.
          15. Haiyun Xu, Xinying Zhang*, Yan He, Shenghai Guo, and Xuesen Fan*. Tandem Reaction of 3-Hydroxyhexa-4,5-allenic Esters: a Novel Access to Diversely Substituted 2H-Pyran-2-ones and Indenes. Chem Commun., 2012, 48, 3121-3123.
          14. Xinying Zhang*, Xuefei Jia, Jianji Wang, and Xuesen Fan*. An Economically and Environmentally Sustainable Synthesis of 2-Aminobenzothiazoles and 2-Aminobenzoxazoles Promoted by Water. Green Chem., 2011, 13, 413-418.
          13.Xinying Zhang,* Xuefei Jia, Liangliang Fang, Nan Liu, Jianji Wang, and Xuesen Fan*. Tandem Reactions of 1,2-Allenic Ketones Leading to Substituted Benzenes and α,β-Unsaturated Nitriles.Org. Lett., 2011, 13, 5024-5027.
          12. Xuesen Fan*, Yangyang Wang, Yingying Qu, Haiyun Xu, Yan He, Xinying Zhang*, and Jianji Wang. Tandem Reactions Leading to Bicyclic Pyrimidine Nucleosides and Benzopyran-4-ones. J. Org. Chem., 2011, 76, 982-985.
          11. Xinying Zhang*, Dongfang Li, Xuefei Jia, Jianji Wang, and Xuesen Fan*. CuI/[bmim]OAc in [bmim]PF6: a Highly Efficient and Readily Recyclable Catalytic System for the Synthesis of 2,3-Disubstituted Benzo[b]furans. Catal. Commun., 2011, 12, 839-843.
          10. Xinying Zhang, Dongfang Li, Xuesen Fan*, Xia Wang, Xiaoyan Li, Guirong Qu*, Jianji Wang. Ionic Liquid-promoted Multi-component Reaction: Novel and Efficient Preparation of Pyrazolo[3,4-b]pyridineone, Pyrazolo[3,4-b]quinolinone and their Hybrids with Pyrimidine Nucleoside. Mol. Divers., 2010, 14, 159-167.
          9. Xinying Zhang, Yingying Qu, Xuesen Fan*, C. Bores, Dong Feng, Graciela Andrei, Robert Snoeck, Erik De Clercq, and Philippe M. Loiseau. Solvent-free Synthesis of Pyrimidine Nucleoside-aminophosphonate Hybrids and their Biological Activity Evaluation. Nucleosides, Nucleotides and Nucleic Acids.,2010, 29, 616-627.
          8. Xinying Zhang, Xiaoyan Li, Dongfang Li, Guirong Qu*, Jianji Wang, Xuesen Fan*.  Ionic Liquid Mediated and Promoted Eco-friendly Preparation of Thiazolidinone and Pyrimidine Nucleoside-thiazolidinone Hybrids and Their Antiparasitic Activities. Bioorg. Med. Chem. Lett., 2009, 19, 6280-6283.
          7. Xinying Zhang*, Xiaoyan Li, Xuesen Fan*, Xia Wang, Jianji Wang and Guirong Qu. Controllable Synthesis of Pyrazolo[3,4-b]pyridines or Substituted Malononitrile Derivatives through Multi-component Reactions in Ionic Liquid. Aust. J. Chem.,2009, 62, 382-388.
          6. Xinying Zhang, Adel Amer, Xuesen Fan, Jan Balzarini, Johan Neyts, Erik De Clercq, Mark Prichard, Earl Kern and Paul F. Torrence*. Synthesis and Antiviral Activities of New Acyclic and “Double-Headed” Nucleoside Analogues. Bioorg. Chem., 2007, 35, 221-232.
          5. Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, and Paul F. Torrence*.5-(Dimethoxymethyl)-2'-deoxyuridine: a Novel Gem Diether Nucleoside with Anti-orthopoxvirus activity. J. Med. Chem., 2006, 49, 3377-3382.
          4. Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Mark N. Prichard, Earl R. Kern, and Paul F. Torrence*.Toward Orthopoxvirus Countermeasures: a Novel Heteromorphic Nucleoside of Unusual Structure. J. Med. Chem., 2006, 49, 4052-4054.
          3. Xuesen Fan, Xinying Zhang, Longhu Zhou, Kathy A. Keith, Earl R. Kern, and Paul F. Torrence*. Assembling a Smallpox Biodefense by Interrogating 5-Substituted Pyrimidine Nucleoside Chemical Space. Antiviral Res., 2006, 71, 201-205. 
          2. Xinying Zhang*, Lingjun Li and Guisheng Zhang. An Efficient and Green Procedure for the Preparation of Acylals from Aldehydes Catalyzed by Fe2(SO4)3·xH2O. Green Chem., 2003, 5, 646-648. 
          1. Xinying Zhang, Xuesen Fan, Hongying Niu and Jianji Wang*. An Ionic Liquid as a Recyclable Medium for the Green Preparation of α,α’-Bis(substituted benzylidene)cycloalkanones Catalyzed by FeCl3·6H2O. Green Chem., 2003, 5, 267-269.

                       
           
          
			        	
          
			        	
          
			        	
          

						
          
			        
			    
          
		    
          
    	
          
    
          



    




          
	
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