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          陳長(zhǎng)坡個(gè)人簡(jiǎn)介
          
			        	
          時(shí)間：2016-06-28瀏覽：6508設(shè)置
          
			        	
			        	
          
			            	

           

          博士，教授，博士生導(dǎo)師，河南師范大學(xué)特聘教授
          河南省高等學(xué)?；づc制藥專(zhuān)業(yè)教學(xué)指導(dǎo)委員會(huì)副主任委員
          河南省化工學(xué)會(huì)第一屆教育工作委員會(huì)副主任委員
          中國(guó)老年骨科學(xué)會(huì)基礎(chǔ)學(xué)組專(zhuān)家委員會(huì)委員
                  
           
           
          教育經(jīng)歷：
          1999/9-2002/7，北京大學(xué)，藥物化學(xué)，博士，導(dǎo)師：張禮和院士
          1988/9-1991/4，北京理工大學(xué)，應(yīng)用化學(xué)，工學(xué)碩士，導(dǎo)師：陳恬生教授
          1984/9-1988/7，河南大學(xué)，化學(xué)，學(xué)士
          工作經(jīng)歷：
          2014/6-至今，  河南師范大學(xué)，化學(xué)化工學(xué)院，特聘教授，教授
          2005/12-2014/5 (美國(guó))托馬斯杰弗遜大學(xué)，醫(yī)學(xué)院，助理研究員，研究員
          2003/2-2005/12 (美國(guó))愛(ài)荷華大學(xué)，藥學(xué)院，博士后
          1995/11-1999/8 化學(xué)工業(yè)部、國(guó)家石化局高級(jí)工程師，
          1991/4-1995/11 北京市發(fā)酵工業(yè)研究所，工程師
          主講課程：
          《藥物設(shè)計(jì)學(xué)》《生物綴合物化學(xué)》
          研究領(lǐng)域與興趣：
          1.    小分子腫瘤免疫治療藥物的設(shè)計(jì)合成與活性
          2.   人工離子通道的設(shè)計(jì)合成與功能表征
          主持或參加科研項(xiàng)目：
          1.    NSF 21977025 國(guó)家自然科學(xué)基金面上項(xiàng)目    含三氮唑模塊的環(huán)二核苷酸類(lèi)似物的設(shè)計(jì)合成與免疫活性研究， 2020.1-2023.12, 66萬(wàn)元, 主持
          2.    NSF U1604285國(guó)家自然科學(xué)基金委-河南省聯(lián)合基金(重點(diǎn)項(xiàng)目)     2′,3′-環(huán)鳥(niǎo)苷腺苷酸類(lèi)似物的設(shè)計(jì)、合成與構(gòu)效關(guān)系研究，2017.1-2020.12, 215萬(wàn)元，第一參與人
          3.    NSF 21605041 國(guó)家自然科學(xué)基金青年基金    靶向干擾素刺激因子的免疫分子機(jī)制、虛擬篩選及生物活性研究， 2017.1-2019.12 30萬(wàn)元，第一參與人。
          代表性論文：
          1. Pengyang Xin,* Lingyu Zhao, Linlin Mao, Linqi Xu, Shuaimin Hou, Huiyuan Kong, Haodong Fang, Haofeng Zhu, Tao Jiang, Chang-Po Chen*, Effect of ChargeStatuson theIon Transport and Antimicrobial Activityof Synthetic Channels. Chem. Commun., 2020,56, 13796-13799.
          2. Shengrui Xu, Qingqing Liu, Cuicui Wang, Li Xiao, Suling Feng*, Ning Li, Chang-Po Chen*, Three-demensional prmpon -like Au/ZnO porous microspheres as solid phase microextraction coating for determination of volatile fatty acids from foot odor. Talanta, 2020, 209, 120519.
          3. Yanwei Chi, Zhiying Wang, Jie Wang, Wenpei Dong, Pengyang Xin, Jingjing Bi, Tao Jiang*, Chang-Po Chen*, Dimeric camptothecin-loaded mPEG-PCL nanoparticles with high drug loading and reduction-responsive drug release. Coloid Polym. Sci., 2020, 298, 51–58.
          4. 陳長(zhǎng)坡*，李寧，徐生瑞，胡宗杰，健康人體足部揮發(fā)性物質(zhì)形成及分析研究進(jìn)展。河南師范大學(xué)學(xué)報(bào)（自然科學(xué)版），2019，47（5），57-64.
          5. Jingjing Guo*，Jie Wang, Jingrong Fan, Yan Zhang, Wenpei Dong, and Chang-Po Chen*, Distinct Dynamical and Conformational Features of Human STING in Response to 2'3'-cGAMP and c-di-GMP. ChemBioChem, 2019, 20(14), 1838-1847.
          6. Tao Jiang, Xin Wang, Ge Wang, Yafu Wang, Kui Wang, Xiaopeng Xuan, Changpo Chen,* Kai Jiang, Hua Zhang,* Light-activated “cycle reversible ICT” fluorescent probe: Monitoring of pHi trace-change induced by UV in programmed cell death.Chem. Comm., 2019, 55, 5279-5282.
          7. Pengyang Xin*, Huiyuan Kong, Yonghui Sun, Lingyu Zhao, Haodong Fang, ,Haofeng Zhu, Tao Jiang, Jingjing Guo, Qian Zhang, Wenpei Dong, Chang-Po Chen* Artificial K+ Channels Formed by Pillararene-Cyclodextrin Hybrid Molecules: , Tuning Cation Selectivity and Generating Membrane Potential. Angew. Chem. Int. Edit. 2019, 58(9): 2779-2784.
          8. Pardeep Kumar, Suhil K. Ttripathi, Chang-Po Chen, Eric Wickstrom, Mathew L. Thakur*. Evaluating Ga-68 peptide conjugates for targeting VPAC receptors: stability and pharmacokinetics. Mol. Imaging Biol. 2019, 21, 130-39.
          9. Lingjun Li*, Xiaofang Xing, Chi Zhang, Anlian Zhu, Xincui Fan, Chang-Po Chen, Guisheng Zhang*. Novel synthesis of 5-iodo-1,2,3-triazoles using an aqueous iodination system under air. Tetrahedron Lett. 2018, 59, 3563-3566. 
          10. Pengyang Xin,* Yonghui Sun, Huiyuan Kong, Yaodong Wang, Si Tan, Jingjing Guo, Tao Jiang, Wenpei Dong, * Chang-Po Chen* A unimolecular channel fromed by dual helical peptide modified pillar[5]arene: correlating transmembrane transport properties with antimicrobial activity and haemolytic toxicity Chem. Comm. 2017, 53, 11492-11495
          11. Lingling Li, Luyao Liu, Chang-Po Chen*, Fengling Cu*, Green synthesis of nitrogen-doped carbon dots from ginkgo fruits and the application in cell imaging. Inorg. Chem. Comm. 2017, 86, 227-231.
          12. Chang-Po Chen, Rui-Yan Jing, and Eric Wickstrom*. Covalent attachment of daptomycin to Ti6Al4V alloy surfaces by a thioether linkage to inhibit colonization by Staphylococcus aureus. Acs Omega 2017, 2(4), 1645-1652.
          13. Pengyang Xin,* Si Tan, Yonghui Sun, Qiaojv Ren,Wenpei Dong, Jingjing Guo, Tao Jiang and Chang-Po Chen* One-pot formation of hydrazide macrocycles with modified cavities: an example of pH-sensitive unimolecular cation channels. Chem. Comm. 2017, 52, 5322-5325.
          14. Pengyang Xin,* Si Tan, Yaodong Wang, Yonghui Sun, Yan Wang, Yuqing Xu and Chang-Po Chen* Functionalized hydrazide macrocycle ion channels showing pH-sensitive ion selectivities. Chem. Comm. 2017, 53, 625-628.
          15. Lingjun Li* Shengqiang Ding, Yanping Yang, Anlian Zhu, Xincui Fan, Mengchao Cui*, Changpo Chen, Guisheng Zhang* Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles:Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling. Chem. Eur. J. 2017, 23, 1166 – 1172
          16. Pardeep Kumar, Sushil Kumar Tripathi, Chang-Po Chen, Neil Mehta, Bishnuhari Paudyal, Eric Wickstrom, Mathew L. Thakur*. Evaluation of a PACAP peptide analogue labeled with 68Ga using two different chelating agents. Cancer Biother. Radiopharm. 2016 31(1):29-36.
          17. Mahesh V. Sonar, Matthew E. Wampole, Yuan-Yuan Jin, Chang-Po Chen, Mathew L. Thakur, Eric Wickstrom*.Fluorescence detection of KRAS2 mRNA hybridization in lung cancer cells with PNA-peptides containing an internal thiazole orange. Bioconj. Chem., 2014, 25, 1697-1708.
          18. Paudyal, B.*, Zhang, K., Chen, C.P., Metha, N., Wampole, M.E., Mitchell, E. P., Gray, B. D., Mattis, J. A., Park, K.Y., Thakur, M. l., and Wickstrom, E. Determining efficacy of breast cancer therapy by PET imaging of HER2 mRNA. Nucl. Med. Biol. 2013, 40, 994-999.
          19. Sanders, J. M., Wampole, M. E., Chen, C.P., Thakur, M. L., and Wickstrom, E*. Effects of hypoxantine substitution in peptide nucleic acids targeting KRAS2 oncogenic mRNA molecules: theory and experiment.J. Phys. Chem. B. 2013117(39):11584–11595.
          20. Sethi ,D.; Chen, C.P.; Jing, R.Y.; Thakur, M.L., and Wickstrom, E*. Fluorescent peptide-PNA chimeras for imaging monoamine oxidase A mRNA in neuronal cells. Bioconj. Chem, 2012, 23(2):158-163.
          21. Thakur, M. L.*；Zhang, K.; Paudyal, B.; Devakumar, D.; Covarrubias, M.; Chen, C.-P.; Gray, B. D.; Wickstrom, E.; Pak, K.-Y. Targeting apoptosis for optical imaging of infection. Mol. Imag. and Biol., 2012, 14(2), 163-171.
          22. Wickstrom, E.; Chen, C.-P.; Devadhas, D.; Wampole, M.; Jin, Y.-Y.; Sanders, J. M.; Kairys, J. C.; Ankeny, M. L.; Hu, R.; Barner, K. E.; Steiner, K. V.; Thakur, M. L.* Three dimensional projection environment for molecular design and surgical simulation. Studies in Health Technol. and Inform. 2011, 163:691-695.
          23. Chen, C. P.; Wickstrom, E*. Self-Protecting Bactericidal Titanium Alloy Surface Formed by Covalent Bonding of Daptomycin Bisphosphonates. Bioconj. Chem. 2010, 21(11), 1978–1986.
          24. Chen, C. P.; Kim, J.; Liu, D.; Rettig, G. R.; McAnuff, M. A.; Martin, M. E.; and Rice, K. G.* Synthetic PEGylated Glycoproteins and Their Utility in Gene Delivery. Bioconj. Chem. 2007, 18(2), 371-378.
          25. Cesarone, G.; Edupuganti, O. P.; Chen, C. P.; Wickstrom, E*. Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analog of insulin-like growth factor 1. Bioconj. Chem. 2007, 18(6), 1831-1840.
          26. Chen, C. P.; Zeiger A. R.; Wickstrom E. Bactericidal activity of extended 9-glycyl-amido-minocycline.  Bioorg. Med . Chem. Lett. 2007,17, 6558-6562.
          27. Chen, C. P.; Kim, J.; Steenblock, E.; Liu, D.; and Rice, K. G*.Gene Transfer with Poly-Melittin Peptides. Bioconj. Chem, 2006, 17(4), 1057-1062.
          28. Kim, J.; Chen, C. P.; Rice, K. G*.The Proteasome Metabolizes Peptide-Mediated Nonviral Gene Delivery Systems. Gene Ther. 2005, 12(21), 1581-1590. 
          29. Chen, C. P.; Park, Y.; Rice, K. G. * An Improved Large-Scale Synthesis of PEG-Peptides for Gene Delivery. J. Pept. Res. (changed name to Chemical Biology and Drug Design, ) 2004, 64(6), 237-243.
          30. Chen, C. P.; Zhang, L. R.; Peng, Y. F.; Wang, X. B.; Wang, S. Q.; Zhang, L. H.* A Concise Method for the Preparation of Peptide and Arginine-Rich Peptide-Conjugated Antisense Oligonucleotide. Bioconj. Chem. 2003, 14(3), 532-538.
          31. Chen, C. P.; Li, X. X.; Zhang, L. R.; Min, J. M.; Chan, J. Y. W.; Fung, K. P.; Wang, S. Q.; Zhang, L. H.* Synthesis of Antisense Oligonucleotide-peptide conjugate Targeting to GLUT-1 in HepG-2 and MCF-7 Cells. Bioconj. Chem. 2002,13(3), 525-529.
          32. Chen, C.P.; Min, J.M.; Zhang, L.H.* Synthesis and Properties of Peptide-Oligonucleotide Conjugates. Prog. Biochem. Biophys. 2001,28(6),783-787.
           
           




          
			        	
          
			        	
          
			        	
          

						
          
			        
			    
          
		    
          
    	
          
    
          



    




          
	
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