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          李凌君個(gè)人簡(jiǎn)介

          時(shí)間:2013-04-09瀏覽:17963設(shè)置

           

          李凌君  博士,教授,博士生導(dǎo)師

          河南省特聘教授,化學(xué)生物學(xué)研究所所長(zhǎng),河南省科技創(chuàng)新杰出青年,高??萍紕?chuàng)新人才支持計(jì)劃獲得者,河南省教育廳學(xué)術(shù)技術(shù)帶頭人,入選河南省高層次人才國(guó)際化培養(yǎng)計(jì)劃。主要從事化學(xué)生物學(xué)和生物有機(jī)化學(xué)研究。主持國(guó)家自然科學(xué)基金4項(xiàng),第一或通訊作者在JACSSCI期刊發(fā)表學(xué)術(shù)論文20余篇,論文被引用1000余次,授權(quán)發(fā)明專利8件,受邀在國(guó)際和全國(guó)學(xué)術(shù)會(huì)議做大會(huì)報(bào)告和邀請(qǐng)報(bào)告6次,研究成果被國(guó)內(nèi)外學(xué)術(shù)媒體連續(xù)采訪報(bào)道。Email: Lingjunlee@htu.cn

           
           
           

          教育與研究經(jīng)歷:

          1997,09- 2001,07河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院化學(xué)教育專業(yè)理學(xué)學(xué)士 

          2001,09 - 2004,07河南師范大學(xué)化學(xué)與環(huán)境科學(xué)學(xué)院有機(jī)化學(xué)專業(yè)理學(xué)碩士

          2004,08 -2007,07 北京大學(xué)藥學(xué)院,天然產(chǎn)物與仿生藥物國(guó)家重點(diǎn)實(shí)驗(yàn)室,化學(xué)生物學(xué)專業(yè)博士

          2009,12-2010,06美國(guó)內(nèi)華達(dá)大學(xué)醫(yī)學(xué)院,生理學(xué)系,NIH訪問(wèn)學(xué)者

          2011, 12- 2012.12美國(guó)Scripps研究所,化學(xué)生物學(xué)專業(yè)博士后

          2007,07-至今河南師范大學(xué)化學(xué)與化工學(xué)院副教授,教授
          主講課程:

          《化學(xué)生物學(xué)概論》,《核酸藥物化學(xué)》,《波譜分析與實(shí)驗(yàn)》

          研究領(lǐng)域與興趣:

          核酸化學(xué)生物學(xué),生物有機(jī)化學(xué),高通量化學(xué)生物學(xué)方法

          近年來(lái)主持的主要科研項(xiàng)目:

          國(guó)家自然科學(xué)基金項(xiàng)目(21778015): 蛋白質(zhì)ADP-核糖化穩(wěn)定結(jié)構(gòu)模擬物的設(shè)計(jì)合成及化學(xué)遺傳學(xué)研究(2018-2021)

          國(guó)家自然科學(xué)基金項(xiàng)目(21172058): 基于靶導(dǎo)向合成(TGS)策略新型NAD+類似物的設(shè)計(jì)合成及活性研究(2012-2015)

          河南省科技創(chuàng)新杰出青年支持計(jì)劃(164100510020:基于人造基因密碼的核酸定點(diǎn)標(biāo)記技術(shù)及應(yīng)用(2016-2018

          河南省高校創(chuàng)新人才支持計(jì)劃(2012HASTIT10): 新型核苷酸類細(xì)胞信號(hào)分子的設(shè)計(jì)合成及活性研究(2012-2014)

          國(guó)家自然科學(xué)基金項(xiàng)目(20802017): 基于click化學(xué)的新型簡(jiǎn)單結(jié)構(gòu)cADPR 類似物的設(shè)計(jì)合成及活性研究 (2009-2011)


          代表性論文:

          1. Feldman, Aaron W.;? Dien, Vivian T.;? Karadeema, Rebekah J.; Fischer, Emil C.; You, Yanbo; Chen, Jason S; Li, Lingjun.*; Romesberg, Floyd. E.* Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism. J. Am. Chem. Soc. 2019, 141 (27), 10644-10653. (IF = 14.357)

          2. Li, Lingjun; Degardin, Melissa; Lavergne, Thomas; Malyshev, Denis A.; Dhami, Kirandeep; Ordoukhanian, Phillip; Romesberg, Floyd E.* Natural-like Replication of an Unnatural Base Pair for the Expansion of the Genetic Alphabet and Biotechnology Applications. J. Am. Chem. Soc. 2014, 136 (3), 826-829. (IF = 14.357) 

          3. Zhang, Yorke; Lamb, Brian M; Feldman, Aaron W; Zhou, Anne Xiaozhou; Lavergne, Thomas; Li, Lingjun; Romesberg, Floyd E*. A semisynthetic organism engineered for the stable expansion of the genetic alphabet.  Proc. Natl. Acad. Sci. U S A 2017, 114 (6), 1317-1322. (IF = 9.674) 

          4. Zhu, Anlian; Li, Lingjun;* Zhang, Chi; Shen Yutan; Tang, Mingjie, Bai, Lili; Du, Chunyan; Zhang, Suojiang; Wang, Jianji* An Integrated High-throughput Strategy Enables the Discovery of Multifunctional Ionic Liquids for Sustainable Chemical Processes. Green Chem. 2019, 21(2), 307-313. (IF = 9.405) 

          5. Zhu, Anlian;* Xing, Xiaofang; Wang, Shilei; Yuan, Donghe; Zhu, Gongmin; Geng, Mingwei; Guo, Yuanyang; Zhang, Guisheng; Li, Lingjun* Multi-component Syntheses of Diverse 5-Fluoroalkyl-1,2,3-triazoles Facilitated by Air Oxidation and Copper Catalysis. Green Chem. 2019, 21 (12), 3407- 3412 (IF = 9.405) 

          6. Li, Lingjun*; Ding, Shengqiang; Yang, Yanping; Zhu, Anlian; Fan, Xincui; Cui, Mengchao*; Chen, Changpo; Zhang, Guisheng*. Multicomponent Aqueous Synthesis of Iodo-1,2,3-triazoles: Single-Step Models for Dual Modification of Free Peptide and Radioactive Iodo Labeling. Chemistry-A European Journal 2017, 23 (5), 1166-1172. (IF = 5.160) 

          7. Li, Lingjun;* Huang, Shenlong; Shang, Tongpeng, Zhang, Bo; Guo, Yuanyang; Zhu, Gongming; Zhou, Demin;* Zhang, Guisheng;* Zhu, Anlian; Zhang Lihe. Medium Rings Bearing Bitriazolyls: Easily Accessible Structures with Superior Performance as Cu Catalyst Ligands. J. Org. Chem. 2018, 83(21), 13166?13177. (IF = 4.85)

          8. Lavergne, T.; Lamichhane, R.; Malyshev, D. A.; Li, Zhengtao Li; Li, Lingjun; Sperling, Edit ; Williamson, James R.; Millar, David P.; Romesberg. Floyd E. FRET Characterization of Complex Conformational Changes in a Large 16S Ribosomal RNA Fragment Site-Specifically Labeled Using Unnatural Base Pairs. ACS Chem. Biol., 2016. 11(5), 1347?1353. (IF = 5.331)




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